日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

基于氮杂肽的SARS-CoV-2主蛋白酶抑制剂:设计、合成、酶抑制、结构鉴定和抗病毒活性

Flury, Philipp; Vishwakarma, Jyoti; Sylvester, Katharina; Higashi-Kuwata, Nobuyo; Dabrowska, Agnieszka K; Delgado, Renee; Cuell, Ashley; Basu, Rahul; Taylor, Alexander B; de Oliveira, Ellen Gonçalves; Magalhães Serafim, Mateus Sá; Qiao, Jingxin; Chen, Yan; Yang, Shengyong; O'Donoghue, Anthony J; Mitsuya, Hiroaki; Gütschow, Michael; Laufer, Stefan A; Müller, Christa E; Harris, Reuben S; Pillaiyar, Thanigaimalai

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species

开发一种对幼年、成年和耐药血吸虫均有效的新型化合物

Alwan, Sevan N; Taylor, Alexander B; McHardy, Stanton F; Cameron, Michael D; LoVerde, Philip T

Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10.

BMP-9 和 BMP-10 中链间二硫键形成的分子基础

Schwartze Tristin A, Morosky Stefanie A, Rosato Teresa L, Henrickson Amy, Lin Guowu, Hinck Cynthia S, Taylor Alexander B, Olsen Shaun K, Calero Guillermo, Demeler Borries, Roman Beth L, Hinck Andrew P

Structures of TGF-β with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling

TGF-β 与 β-聚糖和信号受体的结构揭示了 β-聚糖增强受体复合物组装和信号传导的机制。

Wieteska, Łukasz; Taylor, Alexander B; Punch, Emma; Coleman, Jonathan A; Conway, Isabella O; Lin, Yeu-Farn; Byeon, Chang-Hyeock; Hinck, Cynthia S; Krzysiak, Troy; Ishima, Rieko; López-Casillas, Fernando; Cherepanov, Peter; Bernard, Daniel J; Hill, Caroline S; Hinck, Andrew P

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis

奥沙尼喹衍生物克服了吡喹酮治疗血吸虫病的局限性

Alwan, Sevan N; Taylor, Alexander B; Rhodes, Jayce; Tidwell, Michael; McHardy, Stanton F; LoVerde, Philip T

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

通过迭代过程,可以生产出能杀死感染人类的主要血吸虫种类的奥沙尼喹衍生物。

Guzman, Meghan A; Rugel, Anastasia R; Tarpley, Reid S; Alwan, Sevan N; Chevalier, Frédéric D; Kovalskyy, Dmytro P; Cao, Xiaohang; Holloway, Stephen P; Anderson, Timothy J C; Taylor, Alexander B; McHardy, Stanton F; LoVerde, Philip T

Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction

锌卟啉取代细菌铁蛋白的结构及其还原的光物理性质

Benavides, Brenda S; Valandro, Silvano; Cioloboc, Daniela; Taylor, Alexander B; Schanze, Kirk S; Kurtz, Donald M Jr

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

奥沙尼喹耐药基因在旧大陆曼氏血吸虫中广泛存在,且早于该药物的推广应用。

Chevalier, Frédéric D; Le Clec'h, Winka; McDew-White, Marina; Menon, Vinay; Guzman, Meghan A; Holloway, Stephen P; Cao, Xiaohang; Taylor, Alexander B; Kinung'hi, Safari; Gouvras, Anouk N; Webster, Bonnie L; Webster, Joanne P; Emery, Aidan M; Rollinson, David; Garba Djirmay, Amadou; Al Mashikhi, Khalid M; Al Yafae, Salem; Idris, Mohamed A; Moné, Hélène; Mouahid, Gabriel; Hart, P John; LoVerde, Philip T; Anderson, Timothy J C

Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity.

肺炎支原体社区获得性呼吸窘迫综合征毒素利用新型 KELED 序列进行逆行运输和随后的细胞毒性

Ramasamy Kumaraguruparan, Balasubramanian Sowmya, Manickam Krishnan, Pandranki Lavanya, Taylor Alexander B, Hart P John, Baseman Joel B, Kannan T R

Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents

新型小分子广谱抗血吸虫剂的设计、合成与表征

Rugel, Anastasia; Tarpley, Reid S; Lopez, Ambrosio; Menard, Travis; Guzman, Meghan A; Taylor, Alexander B; Cao, Xiaohang; Kovalskyy, Dmytro; Chevalier, Frédéric D; Anderson, Timothy J C; Hart, P John; LoVerde, Philip T; McHardy, Stanton F