2'-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity
2'-O-(N-(氨基乙基)氨基甲酰基)甲基修饰可在保持活性的前提下降低剪接转换寡核苷酸中的硫代磷酸酯含量。
期刊:Nucleic Acid Therapeutics
影响因子:4.7
doi:10.1089/nat.2021.0086
Honcharenko, Dmytro; Rocha, Cristina S J; Lundin, Karin E; Maity, Jyotirmoy; Milton, Stefan; Tedebark, Ulf; Murtola, Merita; Honcharenko, Malgorzata; Slaitas, Andis; Smith, C I Edvard; Zain, Rula; Strömberg, Roger