日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应。

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Shu Yue, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Zhang Zhong-Yin, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion.

将表型组学与转录组学相结合,揭示了 22q11.2 缺失的细胞类型特异性形态和分子特征

Tegtmeyer Matthew, Liyanage Dhara, Han Yu, Hebert Kathryn B, Pei Ruifan, Way Gregory P, Ryder Pearl V, Hawes Derek, Tromans-Coia Callum, Cimini Beth A, Carpenter Anne E, Singh Shantanu, Nehme Ralda

Genetics of reproductive performance across Porcine Reproductive and Respiratory Syndrome (PRRS) outbreak phases in purebred and crossbred sows

纯种和杂交母猪在猪繁殖与呼吸综合征(PRRS)爆发阶段的繁殖性能遗传学研究

de Oliveira, Leticia F; Dunkelberger, Jenelle; Sevillano, Claudia A; Arirangan, Saranya; Wedow, Robbee; Tegtmeyer, Matthew; Tuinstra, Mitchell; Brito, Luiz F

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds

在“细胞村”中进行基因编辑,可以探索多种遗传背景下与疾病相关的突变。

Battaglia, Rachel A; Bolshakova, Sonia; Mazureac, Ilinca; Liyanage, Dhara; Pettinari, Noah; Johnson, Autumn; Crouse, Ethan; Habib, Sartaj; Flessas, Isabel; Nadig, Ajay; Hawes, Derek; Tegtmeyer, Matthew; Becker, Caroline; Ghosh, Sulagna; Genovese, Giulio; Hogan, Marina; Maglieri, Adrianna; Barrett, Lindy E; Daheron, Laurence; McCarroll, Steven A; Nehme, Ralda

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.

星形胶质细胞提供的胆固醇驱动发育中神经元的突触基因表达程序和下游星形胶质细胞转录程序

Vartiainen Emilia, Liyanage Dhara, Mazureac Illinca, Battaglia Rachel A, Tegtmeyer Matthew, He Jax Xu, Räsänen Noora, Sealock Julia, McCarroll Steven, Nehme Ralda, Pietiläinen Olli

Human genetic variation shapes the response of neurons to interferons.

人类基因变异影响神经元对干扰素的反应

Andzelm Milena M, Bolshakova Sonia, Pettinari Noah, Tegtmeyer Matthew, Meyer Dan, Johnson Autumn, Mello Curtis J, Yu Connie T, Mazureac Ilinca, Genovese Giulio, Maglieri Adrianna, Ichihara Kiku, Hogan Marina, Hawes Derek, McCarroll Steven A, Nehme Ralda

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应:集合体中的小胶质细胞多样性和反应

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice.

基因疗法可缓解 DBA/2J 小鼠中与 Scn2a 缺陷相关的失神性癫痫

Zhang Zaiyang, Zhang Jingliang, Chen Xiaoling, Deming Brody A, Kant Shivam, Mandal Purba, Kothandaraman Harish, SanMiguel Phillip J, Halurkar Manasi S, Abeyaratna Akila D, Robinson Morgan J, Zhao Yuanrui, Vitko Yuliia, Gaykema Ronald P, Yuan Chongli, Lanman Nadia A, Tegtmeyer Matthew T, Wang Dan, Gao Guangping, Shi Riyi, Perez-Reyes Edward, Yang Yang

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

小分子筛选揭示了调控干细胞来源星形胶质细胞中C4分泌的通路

Rapino, Francesca; Natoli, Ted; Limone, Francesco; O'Connor, Erin; Blank, Jack; Tegtmeyer, Matthew; Chen, William; Norabuena, Erika; Narula, Juhi; Hazelbaker, Dane; Angelini, Gabriella; Barrett, Lindy; O'Neil, Alison; Beattie, Ursula K; Thanos, Jessica M; de Rivera, Heather; Sheridan, Steven D; Perlis, Roy H; McCarroll, Steven A; Stevens, Beth; Subramanian, Aravind; Nehme, Ralda; Rubin, Lee L