日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

KDM4C 抑制剂通过促进组织蛋白酶 L 介导的组蛋白 H3 裂解来阻断基底型乳腺癌的肿瘤生长

Li Zheqi, Peluffo Guillermo, Stevens Laura E, Qiu Xintao, Seehawer Marco, Tawawalla Amatullah, Huang Xiao-Yun, Egri Shawn B, Raval Shaunak, McFadden Maeve, D'Santos Clive S, Papachristou Eva, Kingston Natalie L, Nishida Jun, Evans Kyle E, Seo Ji-Heui, Clement Kendell, Temko Daniel, Ekram Muhammad, Li Rong, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Simeonov Anton, Kales Stephen C, Rai Ganesha, Lal-Nag Madhu, Maloney David J, Jadhav Ajit, Michor Franziska, Meissner Alex, Balko Justin M, Carroll Jason S, Freedman Matthew L, Jaffe Jacob D, Papanastasiou Malvina, Long Henry W, Polyak Kornelia

The evolutionary landscape of colorectal tumorigenesis

结直肠肿瘤发生的演化图景

Cross, William; Kovac, Michal; Mustonen, Ville; Temko, Daniel; Davis, Hayley; Baker, Ann-Marie; Biswas, Sujata; Arnold, Roland; Chegwidden, Laura; Gatenbee, Chandler; Anderson, Alexander R; Koelzer, Viktor H; Martinez, Pierre; Jiang, Xiaowei; Domingo, Enric; Woodcock, Dan J; Feng, Yun; Kovacova, Monika; Maughan, Tim; Jansen, Marnix; Rodriguez-Justo, Manuel; Ashraf, Shazad; Guy, Richard; Cunningham, Christopher; East, James E; Wedge, David C; Wang, Lai Mun; Palles, Claire; Heinimann, Karl; Sottoriva, Andrea; Leedham, Simon J; Graham, Trevor A; Tomlinson, Ian P M

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response

体细胞 POLE 外切酶结构域突变是散发性子宫内膜癌和结直肠癌发生早期事件,决定了驱动突变图谱、克隆性新抗原负荷和免疫反应。

Temko, Daniel; Van Gool, Inge C; Rayner, Emily; Glaire, Mark; Makino, Seiko; Brown, Matthew; Chegwidden, Laura; Palles, Claire; Depreeuw, Jeroen; Beggs, Andrew; Stathopoulou, Chaido; Mason, John; Baker, Ann-Marie; Williams, Marc; Cerundolo, Vincenzo; Rei, Margarida; Taylor, Jenny C; Schuh, Anna; Ahmed, Ahmed; Amant, Frédéric; Lambrechts, Diether; Smit, Vincent Thbm; Bosse, Tjalling; Graham, Trevor A; Church, David N; Tomlinson, Ian