Tentler John相关文献与解析，生知库 | 链接生命科学的每一步

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

用于治疗实体瘤的I类选择性组蛋白去乙酰化酶抑制剂OKI-179的临床前开发

Diamond, Jennifer R; Pitts, Todd M; Ungermannova, Dana; Nasveschuk, Christopher G; Zhang, Gan; Phillips, Andrew J; Bagby, Stacey M; Pafford, Jessica; Yacob, Betelehem W; Newton, Timothy P; Tentler, John J; Gittleman, Brian; Hartman, Sarah J; DeMattei, John A; Winkler, James D; Wendt, Michael K; Schiemann, William P; Eckhardt, S Gail; Liu, Xuedong; Piscopio, Anthony D

乙酰化

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发表日期：2022

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WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

在胰腺导管腺癌的临床前模型中，WEE1抑制剂联合靶向药物和标准化疗的疗效

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2021.642328

Hartman, Sarah J; Bagby, Stacey M; Yacob, Betelehem W; Simmons, Dennis M; MacBeth, Morgan; Lieu, Christopher H; Davis, S Lindsey; Leal, Alexis D; Tentler, John J; Diamond, Jennifer R; Eckhardt, S Gail; Messersmith, Wells A; Pitts, Todd M

Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors

TORC1/2抑制剂（TAK-228）与Aurora A激酶抑制剂（Alisertib）联合治疗实体瘤的临床前和剂量探索I期试验结果

期刊:Clinical Cancer Research

影响因子:10.2

doi:10.1158/1078-0432.CCR-19-3498

Davis, S Lindsey; Ionkina, Anastasia A; Bagby, Stacey M; Orth, James D; Gittleman, Brian; Marcus, Joshua M; Lam, Elaine T; Corr, Bradley R; O'Bryant, Cindy L; Glode, Ashley E; Tan, Aik-Choon; Kim, Jihye; Tentler, John J; Capasso, Anna; Lopez, Kyrie L; Gustafson, Daniel L; Messersmith, Wells A; Leong, Stephen; Eckhardt, S Gail; Pitts, Todd M; Diamond, Jennifer R

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

RX-5902 是一种新型 β-catenin 调节剂，可增强免疫检查点抑制剂在三阴性乳腺癌临床前模型中的疗效。

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-020-07500-1

Tentler, John J; Lang, Julie; Capasso, Anna; Kim, Deog Joong; Benaim, Ely; Lee, Young B; Eisen, Andrew; Bagby, Stacey M; Hartman, Sarah J; Yacob, Betelehem W; Gittleman, Brian; Pitts, Todd M; Pelanda, Roberta; Eckhardt, S Gail; Diamond, Jennifer R

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

首创的磷酸化p68抑制剂RX-5902抑制β-catenin信号通路，并在三阴性乳腺癌中展现抗肿瘤活性

期刊:Molecular Cancer Therapeutics

影响因子:5.5

doi:10.1158/1535-7163.MCT-18-1334

Capasso, Anna; Bagby, Stacey M; Dailey, Kyrie L; Currimjee, Naomi; Yacob, Betelehem W; Ionkina, Anastasia; Frank, Julie G; Kim, Deog Joong; George, Christina; Lee, Young B; Benaim, Ely; Gittleman, Brian; Hartman, Sarah J; Tan, Aik Choon; Kim, Jihye; Pitts, Todd M; Eckhardt, S Gail; Tentler, John J; Diamond, Jennifer R

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

polo样激酶抑制剂TAK-960对结直肠癌临床前模型的抗肿瘤活性

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-018-4036-z

Klauck, Peter J; Bagby, Stacey M; Capasso, Anna; Bradshaw-Pierce, Erica L; Selby, Heather M; Spreafico, Anna; Tentler, John J; Tan, Aik Choon; Kim, Jihye; Arcaroli, John J; Purkey, Alicia; Messersmith, Wells A; Kuida, Keisuke; Eckhardt, S Gail; Pitts, Todd M

Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models

在结直肠癌模型中对细胞周期和血管生成激酶进行双重区室靶向调控

期刊:Anti-Cancer Drugs

影响因子:2.2

doi:10.1097/CAD.0000000000000673

Capasso, Anna; Pitts, Todd M; Klauck, Peter J; Bagby, Stacey M; Westbrook, Lindsey; Kaplan, Jeffrey; Soleimani, Milad; Spreafico, Anna; Tentler, John J; Diamond, Jennifer R; Arcaroli, John J; Messersmith, Wells A; Eckhardt, Sue G; Leong, Stephen

"Omics" data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy

“组学”数据整合和功能分析将烯酰辅酶A水合酶短链1与药物难治性扩张型心肌病联系起来

期刊:BMC Medical Genomics

影响因子:2

doi:10.1186/s12920-018-0439-6

Campbell, Nzali V; Weitzenkamp, David A; Campbell, Ian L; Schmidt, Ronald F; Hicks, Chindo; Morgan, Michael J; Irwin, David C; Tentler, John J

Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924)

利用 NEDD8 激活酶抑制剂 pevonedistat (MLN4924) 靶向黑色素瘤中的蛋白质泛素化机制

期刊:Investigational New Drugs

影响因子:2.7

doi:10.1007/s10637-016-0398-8

Wong, Kit Man; Micel, Lindsey N; Selby, Heather M; Tan, Aik Choon; Pitts, Todd M; Bagby, Stacey M; Spreafico, Anna; Klauck, Peter J; Blakemore, Stephen J; Smith, Peter F; McDonald, Alice; Berger, Allison; Tentler, John J; Eckhardt, S Gail

Sensitivity to an inhibitor of translation elongation in solid and hematologic cancers.

对实体瘤和血液肿瘤中翻译延伸抑制剂的敏感性

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

用于治疗实体瘤的I类选择性组蛋白去乙酰化酶抑制剂OKI-179的临床前开发

WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

在胰腺导管腺癌的临床前模型中，WEE1抑制剂联合靶向药物和标准化疗的疗效

Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors

TORC1/2抑制剂（TAK-228）与Aurora A激酶抑制剂（Alisertib）联合治疗实体瘤的临床前和剂量探索I期试验结果

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

RX-5902 是一种新型 β-catenin 调节剂，可增强免疫检查点抑制剂在三阴性乳腺癌临床前模型中的疗效。

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

首创的磷酸化p68抑制剂RX-5902抑制β-catenin信号通路，并在三阴性乳腺癌中展现抗肿瘤活性

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

polo样激酶抑制剂TAK-960对结直肠癌临床前模型的抗肿瘤活性

Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models

在结直肠癌模型中对细胞周期和血管生成激酶进行双重区室靶向调控

"Omics" data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy

“组学”数据整合和功能分析将烯酰辅酶A水合酶短链1与药物难治性扩张型心肌病联系起来

Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924)

利用 NEDD8 激活酶抑制剂 pevonedistat (MLN4924) 靶向黑色素瘤中的蛋白质泛素化机制