Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs
与使用抗GPRC5D双特异性抗体治疗的多发性骨髓瘤患者相比,使用抗BCMA抗体治疗的多发性骨髓瘤患者感染风险增加的根本原因在于选择性B细胞亚群耗竭。
期刊:Blood
影响因子:23.1
doi:10.1182/blood.2025029572
Jelinek, Tomas; Zihala, David; Zabaleta, Aintzane; Kostopoulos, Ioannis V; Soucek, Ondrej; Venglar, Ondrej; Moreno, Cristina; Fotiou, Despina; Radova, Eva; Tamariz-Amador, Luis Esteban; Theodorakakou, Foteini; Muronova, Ludmila; Manubens, Andrea; Tsitsilonis, Ourania; Popkova, Tereza; Gonzalez, Carmen; Anilkumar Sithara, Anjana; Corrado, Francesco; Bidikian, Nayda; Guerrero, Camila; Kapustova, Veronika; Bilek, Daniel; Hagner, Patrick R; Larrayoz, Marta; Martinez Climent, Jose A; Broskevicova, Lucie; Mihalyova, Jana; Merz, Maximilian; Sevcikova, Tereza; Ghobrial, Irene M; San Miguel, Jesus; Dimopoulos, Meletios A; Rodriguez-Otero, Paula; Radocha, Jakub; Kastritis, Efstathios; Paiva, Bruno; Hajek, Roman
B细胞
多发性骨髓瘤
炎症/感染
骨髓瘤
细胞生物学
免疫/内分泌