日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease: An Exploratory Analysis of the SELECT Randomized Clinical Trial

索玛鲁肽与肥胖合并心血管疾病患者的住院情况:SELECT随机临床试验的探索性分析

Nicholls, Stephen J; Ryan, Donna H; Deanfield, John; Ferreira, Daniel; Lang, Chim C; Lincoff, A Michael; Lingvay, Ildiko; Lübker, Christopher; Terns, Paula Pérez; Rasmussen, Søren; Stensen, Signe; Weeke, Peter E; Kahn, Steven E

CRISPR spacers reveal diverse and abundant Thermococcales viruses in hydrothermal vents

CRISPR间隔序列揭示了热液喷口中种类繁多且数量丰富的嗜热球菌病毒

Catchpole, Ryan; McLean, Justin; St John, Emily; Reysenbach, Anna-Louise; Krupovic, Mart; Terns, Michael P

An updated evolutionary classification of CRISPR-Cas systems including rare variants

CRISPR-Cas系统的最新进化分类,包括罕见变异体

Makarova, Kira S; Shmakov, Sergey A; Wolf, Yuri I; Mutz, Pascal; Altae-Tran, Han; Beisel, Chase L; Brouns, Stan J J; Charpentier, Emmanuelle; Cheng, David; Doudna, Jennifer; Haft, Daniel H; Horvath, Philippe; Moineau, Sylvain; Mojica, Francisco J M; Pausch, Patrick; Pinilla-Redondo, Rafael; Shah, Shiraz A; Siksnys, Virginijus; Terns, Michael P; Tordoff, Jesse; Venclovas, Česlovas; White, Malcolm F; Yakunin, Alexander F; Zhang, Feng; Garrett, Roger A; Backofen, Rolf; van der Oost, John; Barrangou, Rodolphe; Koonin, Eugene V

A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity.

噬菌体编码的抗 CRISPR 蛋白利用宿主烯醇化酶来阻止 III 型 CRISPR 免疫。

Johnson Katie A, Goswami Hemant N, Catchpole Ryan J, Ahmadizadeh Fozieh, Zhao Peng, Wells Lance, Li Hong, Terns Michael P

Molecular basis for cA6 synthesis by a type III-A CRISPR-Cas enzyme and its conversion to cA4 production

III-A型CRISPR-Cas酶合成cA6及其转化为cA4的分子基础

Goswami, Hemant N; Ahmadizadeh, Fozieh; Wang, Bing; Addo-Yobo, Doreen; Zhao, Yu; Whittington, A Carl; He, Huan; Terns, Michael P; Li, Hong

Selective degradation of phage RNAs by the Csm6 ribonuclease provides robust type III CRISPR immunity in Streptococcus thermophilus

Csm6核糖核酸酶对噬菌体RNA的选择性降解为嗜热链球菌提供了强大的III型CRISPR免疫力

Johnson, Katie A; Garrett, Sandra C; Noble-Molnar, Christopher; Elgarhi, Hanna A; Woodside, Walter T; Cooper, Clare; Zhang, Xinfu; Olson, Sara; Catchpole, Ryan J; Graveley, Brenton R; Terns, Michael P

A self-transmissible plasmid from a hyperthermophile that facilitates genetic modification of diverse Archaea

来自嗜热菌的可自我转移质粒,可促进多种古菌的基因改造

Catchpole, Ryan J; Barbe, Valérie; Magdelenat, Ghislaine; Marguet, Evelyne; Terns, Michael; Oberto, Jacques; Forterre, Patrick; Da Cunha, Violette

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

IA 型 CRISPR-Cas3 复合物的变构控制及其作为有效核酸检测和人类基因组编辑工具的建立

Hu Chunyi, Ni Dongchun, Nam Ki Hyun, Majumdar Sonali, McLean Justin, Stahlberg Henning, Terns Michael P, Ke Ailong

Unique properties of spacer acquisition by the type III-A CRISPR-Cas system

III-A型CRISPR-Cas系统获取间隔序列的独特特性

Zhang, Xinfu; Garrett, Sandra; Graveley, Brenton R; Terns, Michael P

Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex

体内组装的乳酸乳球菌 CRISPR-Csm 复合物的结构和生化表征

Sagar Sridhara, Jay Rai, Charlisa Whyms, Hemant Goswami, Huan He, Walter Woodside, Michael P Terns, Hong Li