日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR T-cell Resistance via Macrophage Remodeling

肿瘤细胞中GPR65失活通过巨噬细胞重塑驱动抗原非依赖性CAR T细胞耐药性

Jayadev Mavuluri # ,Yogesh Dhungana # ,Lindsay L Jones ,Sheetal Bhatara ,Hao Shi ,Xu Yang ,Song-Eun Lim ,Noemi Reyes ,Hongbo Chi ,Jiyang Yu ,Terrence L Geiger

Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy

基于机制的过氧化物酶3抑制剂利用共价活性基团进行癌症治疗。

Nelson, Kimberly J; Smalley, Terrence L Jr; Messier, Terri; Gumpena, Rajesh; Gandhi, Uma; Milczarek, Stephanie; Habibovic, Aida; Hoffman, Hattie; Gibson, Victoria; Hondal, Robert J; Lowther, W Todd; Cunniff, Brian

Publisher Correction: Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial

出版商更正:Pepinemab抗体阻断SEMA4D治疗早期亨廷顿病:一项随机、安慰剂对照的II期试验

Feigin, Andrew; Evans, Elizabeth E; Fisher, Terrence L; Leonard, John E; Smith, Ernest S; Reader, Alisha; Mishra, Vikas; Manber, Richard; Walters, Kimberly A; Kowarski, Lisa; Oakes, David; Siemers, Eric; Kieburtz, Karl D; Zauderer, Maurice

Integrative multi‐omics epigenome‐wide association study identifies dysregulated DNA methylation near oligodendrocyte genes that associate with tau levels in the AD brain

整合多组学表观基因组关联研究发现,少突胶质细胞基因附近DNA甲基化异常与AD脑内tau蛋白水平相关

Bailey, Rachel M; Howard, John; Knight, Joshua; Sahara, Naruhiko; Dickson, Dennis W; Lewis, Jada; Qi, Qing; Boyle, Rory; Cao, Bolin; Muniz‐Terrera, Graciela; Koychev, Ivan; Malhotra, Paresh; O'Brien, John T; Ritchie, Craig; Lawlor, Brian; Naci, Lorina; Khan, Suleiman; Soliman, Muhammad T; Murray, Sean; Szabo, Jakub; Llanos, Michael; Kim, Hakyoung; Mir, Ema; Santoyo‐Alanis, Daniela; Kingsley, Charles; Swain, Jody; Mulholland, Michele Marie; Hopkins, William D; Wisniewski, Thomas; Veraart, Jelle; Zaim‐Wadghiri, Youssef; Scholtzova, Henrieta; Egerton, Rebecca J; Sweeney, Aoife; McGuinness, Bernadette; Ross, Owen A; Beverland, David; Passmore, Anthony Peter; Heslegrave, Amanda J; Zetterberg, Henrik; Bowman, Emily; Cunningham, Emma L; Sewell, Kelsey R; Solis‐Urra, Patricio; Huang, Haiqing; Grove, George; Kramer, Arthur F; McAuley, Edward; Burns, Jeffrey M; Hillman, Charles; Vidoni, Eric D; Marsland, Anna; Kang, Chaeryon; Wan, Lu; Oberlin, Lauren; Erickson, Kirk I; Evans, Elizabeth E; Fisher, Terrence L Jr; Mishra, Vikas; Balch, Leslie; Gersz, Elaine E; Howell, Alan; Kirk, Renee; Gil‐Moore, Malgorzata; Mallow, Crystal L; Foster, Amber; Porsteinsson, Anton P; Feigin, Andrew; Zauderer, Maurice; Curl, Patti; Walker, Rod L; Donald, Christine L Mac; Andre, Jalal B; McEvoy, Linda K; Ehrlich, Kelly; Crane, Paul K; Watermeyer, Tamlyn J; Butler, Joe; Danso, Samuel O; Russell, John‐Joseph; Parra‐Rodriguez, Mario A; Nir, Talia M; Somu, Sunanda; Low, Kevin; Narula, Siddharth; Villalon‐Reina, Julio E; Gleave, Emma J; Thomopoulos, Sophia I; Lee, Noelle; Braskie, Meredith N; Thompson, Paul M; Jahanshad, Neda; Symanski, Leah E; Breidenbach, Brianne M; Spahic, Alma; Fernandes‐Taylor, Sara; Edmunds, Kyle J; Eisenmenger, Laura B; Rivera‐Rivera, Leonardo A; Driscoll, Ira; Asthana, Sanjay; Johnson, Sterling C; Wieben, Oliver; Okonkwo, Ozioma C; Shi, Hui; Archer, Derek B; Perry, Arden; Pechman, Kimberly R; Shashikumar, Niranjana; Landman, Bennett A; Hohman, Timothy J; Jefferson, Angela L; Full, Kelsie M; Chatterjee, Aadrita; Sirkis, Daniel W; Johnson, Taylor; Pham, Thu; Miller, Bruce L; Rabinovici, Gil D; Wilkins, Heather M; Yaffe, Kristine; Swerdlow, Russell H; Yokoyama, Jennifer S; Andrews, Shea J; Bernabe, Cristian S; Kotredes, Kevin P; Pandey, Ravi S; Carter, Gregory W; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Territo, Paul R; Register, Thomas C; Frye, Brett M; Negrey, Jacob D; Johnson, Corbin SC; Snyder‐Mackler, Noah; Craft, Suzanne; Montine, Thomas J; Shively, Carol A; Oatman, Stephanie R; Reddy, Joseph S; Wang, Xue; Quicksall, Zachary; Atashgaran, Amin; Vanelderen, Floor; Bergman, Jeremiah; Is, Ozkan; Carrasquillo, Minerva M; Liu, Chia‐Chen; Yamazaki, Yu; Nguyen, Thuy; Heckman, Michael G; Zhao, Na; DeTure, Michael; Murray, Melissa E; Bu, Guojun; Kanekiyo, Takahisa; Dickson, Dennis W; Allen, Mariet; Ertekin‐Taner, Nilüfer

Results of SIGNAL‐AD, a randomized, phase 1b/2 trial to evaluate safety and efficacy of targeting reactive astrocytes with pepinemab, SEMA4D blocking antibody, in people with mild Alzheimer’s dementia

SIGNAL-AD 是一项随机、1b/2 期试验,旨在评估使用 SEMA4D 阻断抗体 pepinemab 靶向反应性星形胶质细胞治疗轻度阿尔茨海默病痴呆患者的安全性和有效性。

Janiszewska, Jolanta; Posadas, Inmaculada; Játiva, Pablo; Bugaj-Zarebska, Marta; Urbanczyk-Lipkowska, Zofia; Ceña, Valentín; Martins, Gabriel Colissi; Limberger, Christian; Hoffmeister, Gabriel Lermen; Schmaedek, Mariana Radaelli; de Souza, Ramon Bertoldi; de Oliveira, Roberta dos Santos; Bastiani, Marco Antônio De; Zimmer, Eduardo R; Siemers, Eric R; Evans, Elizabeth E; Fisher, Terrence L Jr; Boise, Megan; Foster, Amber; Leonard, John E; Mishra, Vikas; Mallow, Crystal L; Porsteinsson, Anton P; Turner, Raymond Scott; Bond, Wendy; Huffaker, John; Farlow, Martin R; Honig, Lawrence S; Sheldon, Elizabeth; Townley, Ryan A; Winner, Paul; Norton, Jeffrey; Holub, Richard; Patel, Paayal; Geldmacher, David S; Capote, Horatio; Thein, Stephen; Zauderer, Maurice

Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial

Pepinemab抗体阻断SEMA4D治疗早期亨廷顿病:一项随机、安慰剂对照的II期试验

Feigin, Andrew; Evans, Elizabeth E; Fisher, Terrence L; Leonard, John E; Smith, Ernest S; Reader, Alisha; Mishra, Vikas; Manber, Richard; Walters, Kimberly A; Kowarski, Lisa; Oakes, David; Siemers, Eric; Kieburtz, Karl D; Zauderer, Maurice

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity

Semaphorin 4D 在患病大脑的神经元中上调并引发星形胶质细胞反应

Elizabeth E Evans, Vikas Mishra, Crystal Mallow, Elaine M Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S Smith, Terrence L Fisher, Maurice Zauderer

Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL

输注后CD8+CD19-CAR T细胞的优先扩增以及疾病负荷对儿童B细胞急性淋巴细胞白血病预后的影响

Talleur, Aimee C; Qudeimat, Amr; Métais, Jean-Yves; Langfitt, Deanna; Mamcarz, Ewelina; Crawford, Jeremy Chase; Huang, Sujuan; Cheng, Cheng; Hurley, Caitlin; Madden, Renee; Sharma, Akshay; Suliman, Ali; Srinivasan, Ashok; Velasquez, M Paulina; Obeng, Esther A; Willis, Catherine; Akel, Salem; Karol, Seth E; Inaba, Hiroto; Bragg, Allison; Zheng, Wenting; Zhou, Sheng M; Schell, Sarah; Tuggle-Brown, MaCal; Cullins, David; Patil, Sagar L; Li, Ying; Thomas, Paul G; Zebley, Caitlin; Youngblood, Benjamin; Pui, Ching-Hon; Lockey, Timothy; Geiger, Terrence L; Meagher, Michael M; Triplett, Brandon M; Gottschalk, Stephen

A Plant-Based Dietary Intervention for Preoperative Glucose Optimization in Diabetic Patients Undergoing Total Joint Arthroplasty

一项针对接受全关节置换术的糖尿病患者术前血糖优化的植物性饮食干预研究

Drost, Jennifer M; Cook, Curtiss B; Spangehl, Mark J; Probst, Nicholas E; Mi, Lanyu; Trentman, Terrence L

Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL

Regnase-1抑制TCF-1+前体耗竭T细胞的形成,从而限制CAR-T细胞对ALL的免疫应答。

Zheng, Wenting; Wei, Jun; Zebley, Caitlin C; Jones, Lindsay L; Dhungana, Yogesh; Wang, Yong-Dong; Mavuluri, Jayadev; Long, Lingyun; Fan, Yiping; Youngblood, Ben; Chi, Hongbo; Geiger, Terrence L