日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BRG1 Loss Is Frequent in Lung Cancer and Transforms Lung Epithelial Cells via Transcriptional and Epigenetic Reprograming

BRG1缺失在肺癌中很常见,并通过转录和表观遗传重编程改变肺上皮细胞。

Tessema, Mathewos; Yingling, Christin M; Phillips, Loryn M; Do, Kieu; Picchi, Maria A; Willink, Randy; Belinsky, Steven A

Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

吸入给药可显著提高拓扑替康治疗局部和远处肺癌的疗效。

Kuehl, Philip J; Yingling, Christin M; Dubose, Devon; Burke, Michael; Revelli, David A; Chen, Wenshu; Dye, Wendy W; Belinsky, Steven A; Tessema, Mathewos

5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming.

5-氮胞苷吸入干粉制剂通过基因组重编程显著改善肺癌治疗的药代动力学和疗效

Kuehl Philip J, Tellez Carmen S, Grimes Marcie J, March Thomas H, Tessema Mathewos, Revelli David A, Mallis Larry M, Dye Wendy W, Sniegowski Tyler, Badenoch Aaron, Burke Michael, Dubose Devon, Vodak David T, Picchi Maria A, Belinsky Steven A

Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients

识别新型表观遗传异常作为吸烟者和慢性阻塞性肺病患者痰液中肺癌风险的生物标志物

Tessema, Mathewos; Tassew, Dereje D; Yingling, Christin M; Do, Kieu; Picchi, Maria A; Wu, Guodong; Petersen, Hans; Randell, Scott; Lin, Yong; Belinsky, Steven A; Tesfaigzi, Yohannes

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

在临床前模型中,吸入给药拓扑替康在抑制肺癌方面优于静脉给药。

Kuehl, Philip J; Grimes, Marcie J; Dubose, Devon; Burke, Michael; Revelli, David A; Gigliotti, Andrew P; Belinsky, Steven A; Tessema, Mathewos

Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers

常见癌症驱动突变及其与非吸烟者肺腺癌中异常甲基化基因的关联

Tessema, Mathewos; Rossi, Michael R; Picchi, Maria A; Yingling, Christin M; Lin, Yong; Ramalingam, Suresh S; Belinsky, Steven A

Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop

Muc1基因敲除通过表皮调节素介导的EGFR激活反馈环路增强小鼠肺癌的发生。

Xu, Xiuling; Chen, Wenshu; Leng, Shuguang; Padilla, Mabel T; Saxton, Bryanna; Hutt, Julie; Tessema, Mathewos; Kato, Kosuke; Kim, Kwang Chul; Belinsky, Steven A; Lin, Yong

Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer

CCDC37 和 MAP1B 的表观遗传抑制将慢性阻塞性肺病与肺癌联系起来

Tessema, Mathewos; Yingling, Christin M; Picchi, Maria A; Wu, Guodong; Liu, Yushi; Weissfeld, Joel L; Siegfried, Jill M; Tesfaigzi, Yohannes; Belinsky, Steven A

GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer.

GATA2 在人类和小鼠肺肿瘤中受到表观遗传抑制,并且不是 KRAS 突变肺癌生存所必需的

Tessema Mathewos, Yingling Christin M, Snider Amanda M, Do Kieu, Juri Daniel E, Picchi Maria A, Zhang Xiequn, Liu Yushi, Leng Shuguang, Tellez Carmen S, Belinsky Steven A

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer

CDO1、HOXA9 和 TAC1 癌症特异性甲基化的功能鉴定及其在肺癌诊断中的应用

Wrangle, John; Machida, Emi Ota; Danilova, Ludmila; Hulbert, Alicia; Franco, Noreli; Zhang, Wei; Glöckner, Sabine C; Tessema, Mathewos; Van Neste, Leander; Easwaran, Hariharan; Schuebel, Kornel E; Licchesi, Julien; Hooker, Craig M; Ahuja, Nita; Amano, Jun; Belinsky, Steven A; Baylin, Stephen B; Herman, James G; Brock, Malcolm V