日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

First-in-class anti-human CD45RC antibody targets CD45RC(high) T and B cells to mitigate pathogenic immune responses

首创的抗人CD45RC抗体靶向CD45RC(high) T细胞和B细胞，以减轻致病性免疫反应。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.10.057
Bergua, Cécile; Ahmil-Boiteau, Ghenima; Ouisse, Laure-Hélène; Vimond, Nadège; Sérazin, Céline; Dugast, Lisa; Humeau, Romain; Salama, Apolline; Tesson, Laurent; Swinnen, Katleen; Van Brempt, Ronald; Collette, Alexis; Anegon, Ignacio; Guillonneau, Carole
B细胞
CD45RC
T细胞
CD45
T细胞
细胞生物学
CD4
免疫/内分泌
发表日期：2026
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Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson's disease.

帕金森病 Atp13a2 基因敲除大鼠模型的表型特征分析。

期刊:Npj Parkinsons Disease
影响因子:8.2
doi:10.1038/s41531-025-01171-0
Kinet Rémi, Sikora Joanna, Arotcarena Marie-Laure, Decourt Melina, Balado Eric, Doudnikoff Evelyne, Bohic Sylvain, Vesnaver Marta, Lovisotto Anna, Thiolat Marie-Laure, Dutheil Nathalie, Mazzocco Claire, Harhouri Karim, Steinschneider Rémy, Menoret Severine, Tesson Laurent, Anegon Ignacio, Morari Michele, Vila Miquel, Georges François, Bezard Erwan, Fernagut Pierre-Olivier, Dehay Benjamin
帕金森
发表日期：2025
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Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction

Orai1抑制剂CM5480联合特定疗法可减轻肺动脉高压及其心脏功能障碍

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.191780
Willer, Anaïs Saint-Martin; Ruffenach, Grégoire; Masson, Bastien; El Jekmek, Kristelle; Boët, Angèle; Adão, Rui; Gourmelon, Mathieu; Beauvais, Antoine; Sabourin, Jessica; Dutheil, Mary; Ghigna, Maria-Rosa; Tesson, Laurent; Ménoret, Séverine; Anegon, Ignacio; Bauer, Fabrice; de Montpréville, Vincent; Hebbar, Sudarshan; Brás-Silva, Carmen; Stauderman, Kenneth; Humbert, Marc; Mercier, Olaf; Montani, David; Capuano, Véronique; Antigny, Fabrice
肺动脉高压
心血管
CM5
发表日期：2025
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Generation of a compound heterozygous ABCA4 rat model with pathological features of STGD1.

构建具有 STGD1 病理特征的复合杂合子 ABCA4 大鼠模型

期刊:Human Molecular Genetics
影响因子:3.2
doi:10.1093/hmg/ddaf057
Morival Clément, Croyal Mikaël, Remy Séverine, Mortier Elodie, Libeau Lyse, Veziers Joëlle, Provost Nathalie, Demilly Joanna, Mendes-Madeira Alexandra, Isiegas Carolina, Tesson Laurent, Anegon Ignacio, Adjali Oumeya, Cronin Therese
Rat
发表日期：2025
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CD4(+) and CD8(+) regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model

利用独特的转基因Foxp3-EGFP模型对大鼠CD4(+)和CD8(+)调节性T细胞进行表征

期刊:BMC Biology
影响因子:4.5
doi:10.1186/s12915-022-01502-0
Ménoret, Séverine; Tesson, Laurent; Remy, Séverine; Gourain, Victor; Sérazin, Céline; Usal, Claire; Guiffes, Aude; Chenouard, Vanessa; Ouisse, Laure-Hélène; Gantier, Malika; Heslan, Jean-Marie; Fourgeux, Cynthia; Poschmann, Jeremie; Guillonneau, Carole; Anegon, Ignacio
T细胞
EGF
Rat
CD8
GFP
T细胞
细胞生物学
CD4
免疫/内分泌
发表日期：2023
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Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders

在两种新的16p11.2综合征伴自闭症谱系障碍的非近交系大鼠模型中，MAPK2和KCTD13/CUL3通路改变引起的社会行为变化

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2023.1148683
Martin Lorenzo, Sandra; Muniz Moreno, Maria Del Mar; Atas, Helin; Pellen, Marion; Nalesso, Valérie; Raffelsberger, Wolfgang; Prevost, Geraldine; Lindner, Loic; Birling, Marie-Christine; Menoret, Séverine; Tesson, Laurent; Negroni, Luc; Concordet, Jean-Paul; Anegon, Ignacio; Herault, Yann
信号转导
自闭症
MAPK2
神经科学
MAPK/ERK
Rat
CUL3
发表日期：2023
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Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models

基因组编辑技术的进展及其在构建转基因大鼠模型中的应用

期刊:Frontiers in Genetics
影响因子:2.8
doi:10.3389/fgene.2021.615491
Chenouard, Vanessa; Remy, Séverine; Tesson, Laurent; Ménoret, Séverine; Ouisse, Laure-Hélène; Cherifi, Yacine; Anegon, Ignacio
Rat
发表日期：2021
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Overexpression of endothelial β(3) -adrenergic receptor induces diastolic dysfunction in rats

内皮β(3)-肾上腺素能受体过度表达可诱发大鼠舒张功能障碍

期刊:Esc Heart Failure
影响因子:3.7
doi:10.1002/ehf2.13040
Dhot, Justine; Ferron, Marine; Prat, Valentine; Persello, Antoine; Roul, David; Stévant, David; Guijarro, Damien; Piriou, Nicolas; Aillerie, Virginie; Erraud, Angélique; Toumaniantz, Gilles; Erfanian, Morteza; Tesse, Angela; Grabherr, Amandine; Tesson, Laurent; Menoret, Séverine; Anegon, Ignacio; Trochu, Jean-Noël; Steenman, Marja; De Waard, Michel; Rozec, Bertrand; Lauzier, Benjamin; Gauthier, Chantal
信号转导
Rat
免疫/内分泌
发表日期：2020
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Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment

杜氏肌营养不良症大鼠模型的免疫表型及抗CD45RC抗体治疗后肌肉力量改善的证实

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2019.02131
Ouisse, Laure-Hélène; Remy, Séverine; Lafoux, Aude; Larcher, Thibaut; Tesson, Laurent; Chenouard, Vanessa; Guillonneau, Carole; Brusselle, Lucas; Vimond, Nadège; Rouger, Karl; Péréon, Yann; Chenouard, Alexis; Gras-Le Guen, Christèle; Braudeau, Cécile; Josien, Régis; Huchet, Corinne; Anegon, Ignacio
CD45RC
T细胞
Rat
CD45
CD4
免疫/内分泌
发表日期：2019
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Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9

利用 CRISPR-Cas9 技术构建的两种囊性纤维化大鼠模型（KO 和 F508del CFTR）的特征分析

期刊:Animal Models and Experimental Medicine
影响因子:3.4
doi:10.1002/ame2.12091
Dreano, Elise; Bacchetta, Marc; Simonin, Juliette; Galmiche, Louise; Usal, Claire; Slimani, Lotfi; Sadoine, Jérémy; Tesson, Laurent; Anegon, Ignacio; Concordet, Jean-Paul; Hatton, Aurélie; Vignaud, Lucile; Tondelier, Danielle; Sermet-Gaudelus, Isabelle; Chanson, Marc; Cottart, Charles-Henry
CFTR
Rat
发表日期：2019
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