日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proximal partners of the organellar N-terminal acetyltransferase NAA60: insights into Golgi structure and transmembrane protein topology

细胞器N端乙酰转移酶NAA60的近端伙伴:对高尔基体结构和跨膜蛋白拓扑结构的深入了解

Sebastian Tanco #,Veronique Jonckheere,Arun Kumar Tharkeshwar,Annelies Bogaert,Kris Gevaert,Wim Annaert,Petra Van Damme #

PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells

PMP22 重复导致人类施万细胞发育过程中脂质稳态和质膜组织失调

Robert Prior, Alessio Silva, Tim Vangansewinkel, Jakub Idkowiak, Arun Kumar Tharkeshwar, Tom P Hellings, Iliana Michailidou, Jeroen Vreijling, Maarten Loos, Bastijn Koopmans, Nina Vlek, Cedrick Agaser, Thomas B Kuipers, Christine Michiels, Elisabeth Rossaert, Stijn Verschoren, Wendy Vermeire, Vincen

Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

更正:hiPSCs来源的突变型FUS少突胶质细胞祖细胞中MAM完整性的破坏

Zhu, Yingli; Burg, Thibaut; Neyrinck, Katrien; Vervliet, Tim; Nami, Fatemeharefeh; Vervoort, Ellen; Ahuja, Karan; Sassano, Maria Livia; Chai, Yoke Chin; Tharkeshwar, Arun Kumar; De Smedt, Jonathan; Hu, Haibo; Bultynck, Geert; Agostinis, Patrizia; Swinnen, Johannes V; Van Den Bosch, Ludo; da Costa, Rodrigo Furtado Madeiro; Verfaillie, Catherine

Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

来自 hiPSC 的突变 FUS 少突胶质细胞祖细胞中 MAM 完整性的破坏

Yingli Zhu #, Thibaut Burg, Katrien Neyrinck #, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro

A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore

ALS/FTD 基因 VCP 的致病突变通过调节通透性转换孔来诱导线粒体高代谢

Silke Vanderhaeghe #, Jovan Prerad #, Arun Kumar Tharkeshwar, Elien Goethals, Katlijn Vints, Jimmy Beckers, Wendy Scheveneels, Eveline Debroux, Katrien Princen, Philip Van Damme, Marc Fivaz, Gerard Griffioen, Ludo Van Den Bosch

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

利用 CRISPR/Cas9 技术在人类 iPSC 衍生的皮层神经元中进行筛选,发现 NEK6 是 C9orf72 poly(PR) 毒性的新型疾病修饰因子。

Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; Fan, Yannan; Ahuja, Karan; Moisse, Matthieu; Jacquemyn, Maarten; Furtado Madeiro da Costa, Rodrigo; Gajjar, Madhavsai; Balusu, Sriram; Tricot, Tine; Fumagalli, Laura; Hersmus, Nicole; Janky, Rekin's; Impens, Francis; Vanden Berghe, Pieter; Ho, Ritchie; Thal, Dietmar Rudolf; Vandenberghe, Rik; Hegde, Muralidhar L; Chandran, Siddharthan; De Strooper, Bart; Daelemans, Dirk; Van Damme, Philip; Van Den Bosch, Ludo; Verfaillie, Catherine

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

C9orf72 ALS 中的毒性功能获得机制会损害神经元中的自噬-溶酶体途径

Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor, Raheem Fazal, Dietmar Rudolf Thal, Siddharthan Chandran, Renzo Mancuso, Ludo Van Den Bosch, Philip Van Damme4

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

内质网溶酶体脂质转移蛋白 VPS13C/PARK23 可阻止异常的线粒体 DNA 依赖性 STING 信号传导

William Hancock-Cerutti, Zheng Wu, Peng Xu, Narayana Yadavalli, Marianna Leonzino, Arun Kumar Tharkeshwar, Shawn M Ferguson, Gerald S Shadel, Pietro De Camilli

C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels

C9orf72 ALS-FTD:近期证据表明自噬-溶酶体通路在多个层面存在失调

Beckers, Jimmy; Tharkeshwar, Arun Kumar; Van Damme, Philip

PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

PQLC2 响应阳离子氨基酸饥饿将 C9orf72 复合物募集到溶酶体

Joseph Amick, Arun Kumar Tharkeshwar, Gabriel Talaia, Shawn M Ferguson