日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na(+) Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening

通过表型筛选鉴定具有快速杀灭无性血液期疟原虫活性的α-氮杂环乙酰胺类恶性疟原虫钠泵(PfATP4)抑制剂

Casas, Arturo Jr; Imlay, Leah S; Thathy, Vandana; Fairhurst, Kate J; Lehane, Adele M; Lawong, Aloysus K; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A; Laleu, Benoît; Charman, Susan A; Fidock, David A; Ready, Joseph M; Phillips, Margaret A

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

混合烷基/芳基膦酸酯可识别代谢丝氨酸水解酶作为抗疟靶点

John M Bennett ,Sunil K Narwal ,Stephanie Kabeche ,Daniel Abegg ,Vandana Thathy ,Fiona Hackett ,Tomas Yeo ,Veronica L Li ,Ryan Muir ,Franco Faucher ,Scott Lovell ,Michael J Blackman ,Alexander Adibekian ,Ellen Yeh ,David A Fidock ,Matthew Bogyo

Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine

作者更正:抗疟药物卡巴米喹对突变寄生虫的选择倾向

Stadler, Eva; Maiga, Mohamed; Friedrich, Lukas; Thathy, Vandana; Demarta-Gatsi, Claudia; Dara, Antoine; Sogore, Fanta; Striepen, Josefine; Oeuvray, Claude; Djimdé, Abdoulaye A; Lee, Marcus C S; Dembélé, Laurent; Fidock, David A; Khoury, David S; Spangenberg, Thomas

Correction: A manually curated annotation characterises genomic features of P. falciparum lncRNAs

更正:人工整理的注释描述了恶性疟原虫lncRNA的基因组特征

Hoshizaki, Johanna; Adjalley, Sophie H; Thathy, Vandana; Judge, Kim; Berriman, Matthew; Reid, Adam J; Lee, Marcus C S

Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Pf7:一个包含来自全球20000个样本的恶性疟原虫基因组变异的开放数据集

Abdel Hamid, Muzamil Mahdi; Abdelraheem, Mohamed Hassan; Acheampong, Desmond Omane; Ahouidi, Ambroise; Ali, Mozam; Almagro-Garcia, Jacob; Amambua-Ngwa, Alfred; Amaratunga, Chanaki; Amenga-Etego, Lucas; Andagalu, Ben; Anderson, Tim; Andrianaranjaka, Voahangy; Aniebo, Ifeyinwa; Aninagyei, Enoch; Ansah, Felix; Ansah, Patrick O; Apinjoh, Tobias; Arnaldo, Paulo; Ashley, Elizabeth; Auburn, Sarah; Awandare, Gordon A; Ba, Hampate; Baraka, Vito; Barry, Alyssa; Bejon, Philip; Bertin, Gwladys I; Boni, Maciej F; Borrmann, Steffen; Bousema, Teun; Bouyou-Akotet, Marielle; Branch, Oralee; Bull, Peter C; Cheah, Huch; Chindavongsa, Keobouphaphone; Chookajorn, Thanat; Chotivanich, Kesinee; Claessens, Antoine; Conway, David J; Corredor, Vladimir; Courtier, Erin; Craig, Alister; D'Alessandro, Umberto; Dama, Souleymane; Day, Nicholas; Denis, Brigitte; Dhorda, Mehul; Diakite, Mahamadou; Djimde, Abdoulaye; Dolecek, Christiane; Dondorp, Arjen; Doumbia, Seydou; Drakeley, Chris; Drury, Eleanor; Duffy, Patrick; Echeverry, Diego F; Egwang, Thomas G; Enosse, Sonia Maria Mauricio; Erko, Berhanu; Fairhurst, Rick M; Faiz, Abdul; Fanello, Caterina A; Fleharty, Mark; Forbes, Matthew; Fukuda, Mark; Gamboa, Dionicia; Ghansah, Anita; Golassa, Lemu; Goncalves, Sonia; Harrison, G L Abby; Healy, Sara Anne; Hendry, Jason A; Hernandez-Koutoucheva, Anastasia; Hien, Tran Tinh; Hill, Catherine A; Hombhanje, Francis; Hott, Amanda; Htut, Ye; Hussein, Mazza; Imwong, Mallika; Ishengoma, Deus; Jackson, Scott A; Jacob, Chris G; Jeans, Julia; Johnson, Kimberly J; Kamaliddin, Claire; Kamau, Edwin; Keatley, Jon; Kochakarn, Theerarat; Konate, Drissa S; Konaté, Abibatou; Kone, Aminatou; Kwiatkowski, Dominic P; Kyaw, Myat P; Kyle, Dennis; Lawniczak, Mara; Lee, Samuel K; Lemnge, Martha; Lim, Pharath; Lon, Chanthap; Loua, Kovana M; Mandara, Celine I; Marfurt, Jutta; Marsh, Kevin; Maude, Richard James; Mayxay, Mayfong; Maïga-Ascofaré, Oumou; Miotto, Olivo; Mita, Toshihiro; Mobegi, Victor; Mohamed, Abdelrahim Osman; Mokuolu, Olugbenga A; Montgomery, Jaqui; Morang'a, Collins Misita; Mueller, Ivo; Murie, Kathryn; Newton, Paul N; Ngo Duc, Thang; Nguyen, Thuy; Nguyen, Thuy-Nhien; Nguyen Thi Kim, Tuyen; Nguyen Van, Hong; Noedl, Harald; Nosten, Francois; Noviyanti, Rintis; Ntui, Vincent Ntui-Njock; Nzila, Alexis; Ochola-Oyier, Lynette Isabella; Ocholla, Harold; Oduro, Abraham; Omedo, Irene; Onyamboko, Marie A; Ouedraogo, Jean-Bosco; Oyebola, Kolapo; Oyibo, Wellington Aghoghovwia; Pearson, Richard; Peshu, Norbert; Phyo, Aung P; Plowe, Christopher V; Price, Ric N; Pukrittayakamee, Sasithon; Quang, Huynh Hong; Randrianarivelojosia, Milijaona; Rayner, Julian C; Ringwald, Pascal; Rosanas-Urgell, Anna; Rovira-Vallbona, Eduard; Ruano-Rubio, Valentin; Ruiz, Lastenia; Saunders, David; Shayo, Alex; Siba, Peter; Simpson, Victoria J; Sissoko, Mahamadou S; Smith, Christen; Su, Xin-Zhuan; Sutherland, Colin; Takala-Harrison, Shannon; Talman, Arthur; Tavul, Livingstone; Thanh, Ngo Viet; Thathy, Vandana; Thu, Aung Myint; Toure, Mahamoudou; Tshefu, Antoinette; Verra, Federica; Vinetz, Joseph; Wellems, Thomas E; Wendler, Jason; White, Nicholas J; Whitton, Georgia; Yavo, William; van der Pluijm, Rob W

A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin

恶性疟原虫 Na+ 泵 PfATP4 中的 G358S 突变导致对西帕加明产生临床相关的耐药性

Deyun Qiu #, Jinxin V Pei #, James E O Rosling #, Vandana Thathy, Dongdi Li, Yi Xue, John D Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K Tripathi, Nina F Gnadig, Tomas Yeo, Kate J Fairhurst, Barbara H Stokes, James M Murithi, Krittikorn Kümpornsin, Hea

A manually curated annotation characterises genomic features of P. falciparum lncRNAs

人工整理的注释描述了恶性疟原虫lncRNA的基因组特征

Hoshizaki, Johanna; Adjalley, Sophie H; Thathy, Vandana; Judge, Kim; Berriman, Matthew; Reid, Adam J; Lee, Marcus C S