日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates

多表位TGFβ疫苗在胰腺癌治疗中的应用原理：来自免疫学和临床相关性的证据

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-026-02626-3
Ruders, Josephine Hallundbæk; Ahmad, Shamaila Munir; Mortensen, Rasmus Erik Johansson; Met, Özcan; Byrdal, Mikkel; Chen, Inna Markovna; Theile, Susann; Holmström, Morten Orebo; Andersen, Mads Hald
肿瘤
肿瘤免疫
胰腺癌
TGFβ
免疫/内分泌
发表日期：2026
文献求助 收藏

Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer.

棕榈酰化介导的 KAT2A 调控促进乳腺癌肺转移。

期刊:Nature Cell Biology
影响因子:19.1
doi:10.1038/s41556-026-01913-z
Liu Ming, Vandekeere Anke, Liu Xiao-Zheng, Schenck Stephan, Fernández-García Juan, Tricot Tine, Peng-Winkler Yiming, Demicco Margherita, Broekaert Dorien, Vermeire Ines, Theile Janine, Zels Gitte, Pabba Anirudh, Desmedt Christine, Brunner Janine D, Altea-Manzano Patricia, Fendt Sarah-Maria
乳腺癌
肿瘤
KAT2A
发表日期：2026
文献求助 收藏

Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency

siRNA的非环状丝氨醇核酸修饰可克服种子区介导的脱靶效应，同时保持效力。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkag345
Chickering, Tyler; Harp, Joel M; Jiang, Yongfeng; Qin, June; He, Guo; Hyde, Sarah; Ihlefeld, Audrey; Janas, Maja; O'Flaherty, Derek K; Schofield, Sally; Szeto, John; Theile, Christopher S; Charissé, Klaus; Jadhav, Vasant; Maier, Martin A; Manoharan, Muthiah; Egli, Martin; Schlegel, Mark K
发表日期：2026
文献求助 收藏

THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics

THP-1来源的极化巨噬细胞在药物转运体转录组学、P-糖蛋白活性和利福平摄取动力学方面存在差异。

期刊:Archives of Toxicology
影响因子:6.9
doi:10.1007/s00204-025-04270-2
Hamburg, Katharina; Bay, Cindy; Burhenne, Jürgen; Weiss, Johanna; Stingl, Julia C; Theile, Dirk
巨噬细胞
巨噬细胞
细胞生物学
免疫/内分泌
发表日期：2026
文献求助 收藏

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

胰腺导管腺癌的奥沙利铂耐药性并非主要由药物摄取减少介导，而是与细胞对细胞毒性威胁的凋亡反应较弱密切相关。

期刊:Oncology Reports
影响因子:3.9
doi:10.3892/or.2025.9027
Röttgen, Hellen; Theurer, Lana; Peccerella, Teresa; Sandu, Ketaki; Weiss, Johanna; Burhenne, Jürgen; Neoptolemos, John P; Köberle, Beate; Theile, Dirk
肿瘤
凋亡
表观遗传
肿瘤免疫
细胞生物学
毒理研究
发表日期：2026
文献求助 收藏

Invasive ventilation and mortality in critically ill nonagenarians: a retrospective cohort study

有创通气与危重九旬老人死亡率：一项回顾性队列研究

期刊:European Journal of Medical Research
影响因子:3.4
doi:10.1186/s40001-026-03928-6
Haar, Markus; Gleibs, Fabian; Hertrich, Anna Carola; Müller, Jakob; Daniels, Rikus; Theile, Pauline; Kluge, Stefan; Roedl, Kevin
发表日期：2026
文献求助 收藏

A phase 1b open-label, dose-escalating study of safety and efficacy of disulfiram, copper and vinorelbine in advanced solid tumors

一项针对晚期实体瘤的双硫仑、铜和长春瑞滨的安全性和有效性的 1b 期开放标签、剂量递增研究

期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-026-15743-7
Eefsen, Rikke Løvendahl; Stenvang, Jan; Bartek, Jiri; Pfeiffer, Per; Tarpgaard, Line; Theile, Susann; Brünner, Nils; Nielsen, Dorte L
发表日期：2026
文献求助 收藏

Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia

一项随机II期研究比较了紫杉醇纳米粒联合吉西他滨（加或不加托珠单抗）作为晚期胰腺癌一线治疗方案的疗效：生存率和恶病质

期刊:Journal of Clinical Oncology
影响因子:41.9
doi:10.1200/JCO.23.01965
Chen, Inna M; Johansen, Julia S; Theile, Susann; Silverman, Libbie M; Pelz, Katherine R; Madsen, Kasper; Dajani, Olav; Lim, Kevin Z M; Lorentzen, Torben; Gaafer, Omnia; Koniaris, Leonidas G; Ferreira, Anna C; Neelon, Brian; Guttridge, Denis C; Ostrowski, Michael C; Zimmers, Teresa A; Nielsen, Dorte
胰腺癌
肿瘤
肿瘤免疫
发表日期：2025
文献求助 收藏

Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer

利用游离DNA进行全基因组分析，以监测胰腺癌患者的治疗效果

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ads5002
Hruban, Carolyn; Bruhm, Daniel C; Chen, Inna M; Koul, Shashikant; Annapragada, Akshaya V; Vulpescu, Nicholas A; Short, Sarah; Theile, Susann; Boyapati, Kavya; Alipanahi, Bahar; Skidmore, Zachary L; Leal, Alessandro; Cristiano, Stephen; Adleff, Vilmos; Johannsen, Julia S; Scharpf, Robert B; Foda, Zachariah H; Phallen, Jillian; Velculescu, Victor E
胰腺癌
肿瘤
肿瘤免疫
发表日期：2025
文献求助 收藏

Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake

头颈部鳞状细胞癌的顺铂耐药性与DNA损伤反应和细胞周期阻滞转录组学相关，而非药物吸收不良。

期刊:Cancer Drug Resistance
影响因子:5.2
doi:10.20517/cdr.2025.107
Sandu, Ketaki; Warta, Rolf; Biswas, Uddipta; Zhang, Wang; Michl, Patrick; Herold-Mende, Christel; Weiss, Johanna; Theile, Dirk
细胞生物学
肿瘤
毒理研究
肿瘤免疫
发表日期：2025
文献求助 收藏