日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19

多组学空间分析揭示了SARS-CoV-2独特的肺部微环境,并将胶原蛋白VI作为重症COVID-19的预测性生物标志物。

Fennell, Éanna; Taylor, Graham S; Leahy, Ciara I; Ross, Aisling M; Reynolds, Gary; Perry, Tracey; Youd, Esther; Skidmore, Jacob; Darwish, Radwan Ramzi Radwan; Hunter, Kelly J; Willcox, Benjamin E; Jermann, Philip; Arif Jahangir, Chowdhury; Rahman, Arman; Gallagher, William M; Nikulina, Nadezhda; Ben Cheikh, Bassem; Braubach, Oliver; Mayer, Aaron T; Young, Lawrence S; Grammatopoulos, Dimitris; Faustini, Sian; Richter, Alex; Dowell, Alexander C; Venith, Tonny; Thein, Onn S; Parekh, Dhruv; Belchamber, Kylie B R; Thickett, David R; Scott, Aaron; Attanoos, Richard; Mundo, Lucia; Lazzi, Stefano; Leoncini, Lorenzo; Leopold, Gareth; Steven, Neil; Bülow Sand, Jannie Marie; Karsdal, Morten A; Leeming, Diana Julie; Dojcinov, Stefan; Culhane, Aedin; Murray, Paul G; Pugh, Matthew R

Hospitalised older adults with community-acquired pneumonia and sepsis have dysregulated neutrophil function but preserved glycolysis

患有社区获得性肺炎和脓毒症的住院老年患者中性粒细胞功能失调,但糖酵解功能保持正常

Grudzinska, Frances; Faniyi, Aduragbemi A; Belchamber, Kylie B R; Chen, Celine; Stockley, Robert; Jasper, Alice; Parekh, Dhruv; Sapey, Elizabeth; Scott, Aaron; Thickett, David R

Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model

特异性抑制Orai1介导的钙信号传导可缓解急性呼吸窘迫综合征模型中的炎症并清除细菌

Ahmad, Saira; Wrennall, Joe A; Goriounova, Alexandra S; Sekhri, Malika; Iskarpatyoti, Jason A; Ghosh, Arunava; Abdelwahab, Sabri H; Voeller, Alexis; Rai, Mani; Mahida, Rahul Y; Krajewski, Krzysztof; Ignar, Diane M; Greenbaum, Alon; Moran, Timothy P; Tilley, Stephen L; Thickett, David R; Sassano, M Flori; Tarran, Robert

Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers

英国医护人员维生素D缺乏与新冠肺炎症状持续时间的关系

Chadda, Karan R; Roberts, Sophie A; Lugg, Sebastian T; Faniyi, Aduragbemi A; Faustini, Sian E; Webster, Craig; Duffy, Joanne E; Hewison, Martin; Shields, Adrian; Richter, Alex G; Parekh, Dhruv; Scott, Aaron; Thickett, David R

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID-19 Study

COVID-19 住院后肺部残留异常:UKILD COVID-19 后研究的中期分析

Stewart, Iain; Jacob, Joseph; George, Peter M; Molyneaux, Philip L; Porter, Joanna C; Allen, Richard J; Aslani, Shahab; Baillie, J Kenneth; Barratt, Shaney L; Beirne, Paul; Bianchi, Stephen M; Blaikley, John F; Chalmers, James D; Chambers, Rachel C; Chadhuri, Nazia; Coleman, Christopher; Collier, Guilhem; Denneny, Emma K; Docherty, Annemarie; Elneima, Omer; Evans, Rachael A; Fabbri, Laura; Gibbons, Michael A; Gleeson, Fergus V; Gooptu, Bibek; Greening, Neil J; Guio, Beatriz Guillen; Hall, Ian P; Hanley, Neil A; Harris, Victoria; Harrison, Ewen M; Heightman, Melissa; Hillman, Toby E; Horsley, Alex; Houchen-Wolloff, Linzy; Jarrold, Ian; Johnson, Simon R; Jones, Mark G; Khan, Fasihul; Lawson, Rod; Leavy, Olivia; Lone, Nazir; Marks, Michael; McAuley, Hamish; Mehta, Puja; Parekh, Dhruv; Hanley, Karen Piper; Platé, Manuela; Pearl, John; Poinasamy, Krisnah; Quint, Jennifer K; Raman, Betty; Richardson, Matthew; Rivera-Ortega, Pilar; Saunders, Laura; Saunders, Ruth; Semple, Malcolm G; Sereno, Marco; Shikotra, Aarti; Simpson, A John; Singapuri, Amisha; Smith, David J F; Spears, Mark; Spencer, Lisa G; Stanel, Stefan; Thickett, David R; Thompson, A A Roger; Thorpe, Mathew; Walsh, Simon L F; Walker, Samantha; Weatherley, Nicholas David; Weeks, Mark E; Wild, Jim M; Wootton, Dan G; Brightling, Chris E; Ho, Ling-Pei; Wain, Louise V; Jenkins, Gisli R

Real-time assessment of neutrophil metabolism and oxidative burst using extracellular flux analysis

利用细胞外通量分析实时评估中性粒细胞代谢和氧化爆发

Grudzinska, Frances S; Jasper, Alice; Sapey, Elizabeth; Thickett, David R; Mauro, Claudio; Scott, Aaron; Barlow, Jonathan

Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D

FGF23水平升高与危重疾病患者死亡率增加相关,且与维生素D无关。

Thein, Onn Shaun; Ali, Naeman Akbar; Mahida, Rahul Y; Dancer, Rachel C A; Ostermann, Marlies; Amrein, Karin; Martucci, Gennaro; Scott, Aaron; Thickett, David R; Parekh, Dhruv

Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis - Pneumonia Metabolism in Ageing (PUMA)

观察性队列研究方案:肺炎和脓毒症成人患者的中性粒细胞功能和能量代谢 - 老年肺炎代谢 (PUMA)

Grudzinska, Frances S; Faniyi, Aduragbemi A; Scott, Aaron; Sapey, Elizabeth; Thickett, David R

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

在COVID-19住院患者中,比较Namilumab或英夫利昔单抗与标准治疗方案的疗效(CATALYST):一项随机、多中心、多组、多阶段、开放标签、适应性II期概念验证试验

Fisher, Benjamin A; Veenith, Tonny; Slade, Daniel; Gaskell, Charlotte; Rowland, Matthew; Whitehouse, Tony; Scriven, James; Parekh, Dhruv; Balasubramaniam, Madhu S; Cooke, Graham; Morley, Nick; Gabriel, Zoe; Wise, Matthew P; Porter, Joanna; McShane, Helen; Ho, Ling-Pei; Newsome, Philip N; Rowe, Anna; Sharpe, Rowena; Thickett, David R; Bion, Julian; Gates, Simon; Richards, Duncan; Kearns, Pamela

Real-world evaluation of rapid and laboratory-free COVID-19 triage for emergency care: external validation and pilot deployment of artificial intelligence driven screening

针对急诊护理中快速、无需实验室检测的 COVID-19 分诊的实际应用评估:人工智能驱动筛查的外部验证和试点部署

Soltan, Andrew A S; Yang, Jenny; Pattanshetty, Ravi; Novak, Alex; Yang, Yang; Rohanian, Omid; Beer, Sally; Soltan, Marina A; Thickett, David R; Fairhead, Rory; Zhu, Tingting; Eyre, David W; Clifton, David A