日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2-Deficient Mouse Model

树状聚合物偶联的谷氨酰胺拮抗剂D-TTM020可改善Mecp2缺陷小鼠模型的脑免疫失调并改善其神经行为缺陷。

Vyas, Preeti; Khoury, Elizabeth Smith; Sah, Nirnath; Sharma, Anjali; Allende Labastida, Javier; Wilkinson, Elizabeth L; Lac, Kathleen; Damiba, Nerketa N L; Fowler, Amanda; Liu, Jinhuan; Bedner, Ashley; Majer, Pavel; Tichý, Tomás; Thomas, Ajit G; Rais, Rana; Slusher, Barbara S; Kannan, Rangaramanujam M; Kannan, Sujatha

Discovery of N-Acetyltransferase 8-Like (NAT8L) inhibitors based on a N-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold

基于 N-酰化(哌啶-3-基甲基)-1,2,4-恶二唑骨架的 N-乙酰转移酶 8 样(NAT8L)抑制剂的发现

Nayeen, Md Junayed; Thomas, Ajit G; Kundu, Biswajit; Carlyle, Evan; Hin, Niyada; Hin, Philana; Pal, Arindom; Paule, James; Rais, Rana; Slusher, Barbara S; Tsukamoto, Takashi

Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits

抑制小胶质细胞谷氨酰胺酶可缓解慢性应激引起的神经行为和认知缺陷

Huang, Meixiang; Li, Yannan; Thomas, Ajit G; Sharma, Anjali; Liyanage, Wathsala; Tichý, Tomáš; Tenora, Lukáš; Su, Yu; Ha, Jisu; Hin, Niyada; Obayashi, Mizuho; Majer, Pavel; Kannan, Rangaramanujam M; Tsukamoto, Takashi; Ursini, Gianluca; Rais, Rana; Slusher, Barbara S; Zhu, Xiaolei

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

质谱引导下新型GCPII抑制剂骨架的发现

Wiseman, Robyn; Thomas, Ajit G; Janiszewski, John; Hoxie, Nate; Lee, Chae Bin; Wu, Ying; Tsukamoto, Takashi; Ye, Lin; Ronzetti, Michael; Shrimp, Jonathan H; Adderley, Davina; Rai, Ganesha; Rais, Rana; Alt, Jesse; Hall, Matthew D; Hu, Xin; Kales, Stephen C; Slusher, Barbara S

Neutral sphingomyelinase 2: A promising drug target for CNS disease

中性鞘磷脂酶2:中枢神经系统疾病的一种有前景的药物靶点

Huang, Meixiang; Stremlau, Matthew; Zavras, Jason; Zivko, Cristina; Thomas, Ajit G; Pietri, Peter; Machairaki, Vasiliki; Slusher, Barbara S

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice.

GCPII抑制剂可促进老年小鼠周围神经损伤后的髓鞘再生

Su Yu, Huang Meixiang, Thomas Ajit G, Maragakis John, Huizar Kaitlyn D J, Zheng Yuxin, Wu Ying, Farah Mohamed H, Slusher Barbara S

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

发现肿瘤靶向代谢抑制剂前药DRP-104

Rais, Rana; Lemberg, Kathryn M; Tenora, Lukáš; Arwood, Matthew L; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H; Zhao, Liang; Peters, Diane E; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G; Dash, Ranjeet P; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D; Powell, Jonathan D; Slusher, Barbara S

Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis.

树状聚合物-2PMPA可延缓肌萎缩侧索硬化症小鼠模型中的肌肉功能丧失和神经支配丧失

Tallon Carolyn, Sharma Anjali, Zhang Zhi, Thomas Ajit G, Ng Justin, Zhu Xiaolei, Donoghue Amanda, Schulte Michael, Joe Tawnjerae R, Kambhampati Siva P, Sharma Rishi, Liaw Kevin, Kannan Sujatha, Kannan Rangaramanujam M, Slusher Barbara S

Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)

基于噻吩并[2,3-d]嘧啶的人类Mas相关G蛋白偶联受体X1(MRGPRX1)正向变构调节剂

Berhane, Ilyas; Hin, Niyada; Thomas, Ajit G; Huang, Qian; Zhang, Chi; Veeravalli, Vijayabhaskar; Wu, Ying; Ng, Justin; Alt, Jesse; Rojas, Camilo; Hihara, Hiroe; Aoki, Mika; Yoshizawa, Kyoko; Nishioka, Tomoki; Suzuki, Shuichi; He, Shao-Qiu; Peng, Qi; Guan, Yun; Dong, Xinzhong; Raja, Srinivasa N; Slusher, Barbara S; Rais, Rana; Tsukamoto, Takashi

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

D-多巴是一种强效、口服生物利用度高的谷氨酸羧肽酶II变构抑制剂。

Gori, Sadakatali S; Thomas, Ajit G; Pal, Arindom; Wiseman, Robyn; Ferraris, Dana V; Gao, Run-Duo; Wu, Ying; Alt, Jesse; Tsukamoto, Takashi; Slusher, Barbara S; Rais, Rana