日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma

儿童横纹肌肉瘤的生物学进展和当前挑战

Hebron, Katie E; Odeniyide, Patience; Wei, Yun; Gryder, Berkley E; Barr, Frederic G; Casey, Dana L; Chen, Eleanor Y; Crompton, Brian D; Dela Cruz, Filemon S; Durbin, Adam D; Ford, Heide L; Gatz, Susanne A; Hatley, Mark E; Henssen, Anton G; Hettmer, Simone; Houghton, Peter J; Kendall, Genevieve C; Khan, Javed; Lupo, Philip J; Patel, Anand G; Pomella, Silvia; Rota, Rossella; Schito, Marco; Schoot, Reineke A; Shern, Jack F; Stanton, Benjamin Z; Stewart, Elizabeth A; Swindlehurst, Cathy A; Thomas, Craig J; Vakoc, Christopher R; Vaseva, Angelina V; Venkatramani, Rajkumar; Wexler, Leonard H; Yustein, Jason T; Hammond, Sharon; Heske, Christine M; Langenau, David M; Linardic, Corinne M; Ignatius, Myron S; Yohe, Marielle E

Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168

SLFN11 的泛素依赖性染色质募集受去泛素化酶 (DUB) 和 RNF168 的调控。

Taniyama, Daiki; Pegoraro, Gianluca; Wu, Ying; Huang, Shar-Yin Naomi; Thomas, Craig J; Ozbun, Laurent; Tran, Andy D; Saha, Liton K; Murai, Junko; Jo, Ukhyun; Pommier, Yves

Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.

阐明针对致命性前列腺癌的 MCL1 分子分层单药和联合治疗策略。

Jiménez-Vacas Juan M, Westaby Daniel, Figueiredo Ines, De Haven Brandon Alexis, Padilha Ana, Yuan Wei, Seed George, Bogdan Denisa, Gurel Bora, Bertan Claudia, Miranda Susana, Lambros Maryou, Montero-Hidalgo Antonio J, Coleman Ilsa, Yu Ivan Pak Lok, Buroni Lorenzo, Zeng Wanting, Neeb Antje J, Welti Jon, Rekowski Jan, Paravati Roberta, Gabel Florian, Pandell Nicole, Ferreira Ana, Crespo Mateus, Riisnaes Ruth, Das Souvik, Taylor Joe, Waldron Nick, Hobern Emily, Valenti Melanie, Ning Jian, Bernett Ilona, Liodaki Kate, Persse Thomas, Galipeau Patricia, Wilkinson Scott, Trostel Shana Y, Karzai Fatima, Chau Cindy H, Beatson Erica L, Zhang Xiaohu, Klumpp-Thomas Carleen, Varkaris Andreas, Luque Raul M, Swain Amanda, Raynaud Florence, Lack Nathan A, Thomas Craig J, Ha Gavin, Figg William D, Bezzi Marco, Sowalsky Adam G, Nelson Peter S, Carreira Suzanne, Balk Steven P, de Bono Johann S, Sharp Adam

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization.

靶向 IRAK4 和 GSPT1 可通过 c-Myc 不稳定增强 AML 的治疗效果

Vick Eric J, Hassan Aishlin, Choi Kwangmin, Bennett Joshua, Muto Tomoya, Clough Courtnee A, Culver-Cochran Ashley E, Hueneman Kathleen, Bolanos Lyndsey C, Wunderlich Mark, Zhang Xiaohu, McKnight Crystal, Ceribelli Michele, Holland David, Klumpp-Thomas Carleen, Greis Kenneth D, Thomas Craig J, Starczynowski Daniel T

Designing a time-dependent therapeutic strategy using CDK4/6 inhibitors in an intracranial ATRT model.

在颅内ATRT模型中,利用CDK4/6抑制剂设计时间依赖性治疗策略

Martin Brice, Guadix Sergio W, Sathian Rekha, Laramee Madeline, Pandey Abhinav, Ray Ishani, Wang Amy, Davuluri Ramana, Thomas Craig J, Dahmane Nadia, Souweidane Mark

Discovery and Optimization of LATS1 and LATS2 Kinase Inhibitors for Use in Regenerative Medicine

LATS1和LATS2激酶抑制剂的发现和优化及其在再生医学中的应用

Morris, Patrick J; Duveau, Damien Y; Ceribelli, Michele; Tosto, Frances Anne; Love, Dara N; Scherer, Bridget S; Tao, Dingyin; Fang, Yuhong; Evsen, Lale; Kotler, Samuel A; LeClair, Christopher A; Rai, Ganesha; Thomas, Craig J; Hoyt, Scott B

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.

利用新型 NAMPT 抑制剂 OT-82 靶向 FH 缺陷型遗传性平滑肌瘤病和肾细胞癌中的 NAD+ 代谢脆弱性

Najera Susana S, Ricketts Christopher J, Schmidt Laura S, Medina Julia I, Saito Keita, Ileva Lilia, Brender Jeffrey R, James Amy M, Peer Cody J, Gouker Brad, Karim Baktiar O, Chernova Olga, Wells Catherine, Wei Ming-Hui, Yang Youfeng, Zhang Xiaohu, Klumpp-Thomas Carleen, Travers Jameson, Chen Lu, Wilson Kelli M, Issaq Sameer H, Figg William D, Difilippantonio Simone, Kalen Joseph D, Krishna Murali C, Thomas Craig J, Ceribelli Michele, Heske Christine M, Crooks Daniel R, Meier Jordan L

The Kinase Inhibitor GNF-7 Is Synthetically Lethal in Topoisomerase 1-Deficient Ewing Sarcoma.

激酶抑制剂 GNF-7 在拓扑异构酶 1 缺陷型尤文氏肉瘤中具有合成致死性

Sayers Carly M, Carter Morgan B, Lei Haiyan, Mendoza Arnulfo, Shema Steven, Zhang Xiaohu, Wilson Kelli, Chen Lu, Klumpp-Thomas Carleen, Thomas Craig J, Heske Christine M, Shern Jack F

IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia

降低hERG阻滞的IRAK1/4/泛FLT3激酶抑制剂可治疗急性髓系白血病

Hoyt, Scott B; Finocchio, Chris J; Croll, Elizabeth; Tawa, Gregory J; Zhang, Mingliang; Wang, Jiangong; Li, Huixi; Ma, Li; Li, Kaikai; Zhang, Xiaohu; Xu, Xin; Shah, Pranav; Fang, Yuhong; Bolanos, Lyndsey C; Gracia-Maldonado, Gabriel; Kolt, Amal; Robinson, Christina; Free, Jessica; Edmondson, Elijah F; Difilippantonio, Simone; Jones, LaQuita M; Culver-Cochran, Ashley E; Rosenbaum, Jan S; Starczynowski, Daniel T; Thomas, Craig J

An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors

对几种布鲁顿酪氨酸激酶(BTK)抑制剂的激酶选择性、酶抑制动力学和体外活性进行评估

Corrionero, Ana; Zhang, Xiaohu; Alfonso, Patricia; Morris, Patrick J; Klumpp-Thomas, Carleen; Melani, Christopher; McKnight, Crystal; Phelan, James D; Holland, David; Wilson, Kelli; Hoyt, Scott B; Roschewski, Mark; Tonge, Peter J; Wilson, Wyndham; Ceribelli, Michele; Staudt, Louis M; Thomas, Craig J