日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A.

研究化合物 MCG1516A 可挽救突变 CFTR 转运缺陷

Lopes-Pacheco Miquéias, Bacalhau Mafalda, Ramalho Sofia S, Silva Iris A L, Ferreira Filipa C, Carlile Graeme W, Thomas David Y, Farinha Carlos M, Hanrahan John W, Amaral Margarida D

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

受体胞内结构域的选择性剪接产生不同的胞外结构域构象,从而实现异构体选择性功能配体。

Brahimi, Fouad; Galan, Alba; Jmaeff, Sean; Barcelona, Pablo F; De Jay, Nicolas; Dejgaard, Kurt; Young, Jason C; Kleinman, Claudia L; Thomas, David Y; Saragovi, H Uri

Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells

香烟烟雾通过ROS刺激的cAMP信号通路激活人支气管上皮细胞中的CFTR

Wong, Francis H; AbuArish, Asmahan; Matthes, Elizabeth; Turner, Mark J; Greene, Lana E; Cloutier, Alexandre; Robert, Renaud; Thomas, David Y; Cosa, Gonzalo; Cantin, André M; Hanrahan, John W

Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death

蛋白质组学鉴定出高尔基体磷蛋白3 (GOLPH3) 与高尔基体结构、癌症、DNA损伤和细胞死亡保护之间的联系

Bergeron, John J M; Au, Catherine E; Thomas, David Y; Hermo, Louis

An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases

美国胸科协会官方研讨会报告:罕见呼吸系统疾病的转化研究

Kristof, Arnold S; Petrof, Basil J; Hamid, Qutayba; Kolb, Martin; Landry, Jennifer S; MacKenzie, Alex; McCormack, Francis X; Murawski, Inga J; Moss, Joel; Rauch, Frank; Rosas, Ivan O; Shapiro, Adam J; Smith, Benjamin M; Thomas, David Y; Trapnell, Bruce C; Young, Lisa R; Zariwala, Maimoona A

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor)

低游离药物浓度可防止增强剂 VX-770(伊伐卡托)抑制 F508del CFTR 功能表达。

Matthes, Elizabeth; Goepp, Julie; Carlile, Graeme W; Luo, Yishan; Dejgaard, Kurt; Billet, Arnaud; Robert, Renaud; Thomas, David Y; Hanrahan, John W

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism

卡马西平作为一种新型小分子药物,可纠正先天性高胰岛素血症中发现的转运受损的ATP敏感性钾通道。

Chen, Pei-Chun; Olson, Erik M; Zhou, Qing; Kryukova, Yelena; Sampson, Heidi M; Thomas, David Y; Shyng, Show-Ling

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

能够纠正F508del-CFTR蛋白转运的化合物也能纠正其他蛋白质转运疾病:一项使用细胞系进行的体外研究

Sampson, Heidi M; Lam, Hung; Chen, Pei-Chun; Zhang, Donglei; Mottillo, Cristina; Mirza, Myriam; Qasim, Karim; Shrier, Alvin; Shyng, Show-Ling; Hanrahan, John W; Thomas, David Y

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

Orai1插入细胞质膜后Ca2+内流增强,导致囊性纤维化气道IL-8分泌增加。

Balghi, Haouaria; Robert, Renaud; Rappaz, Benjamin; Zhang, Xuexin; Wohlhuter-Haddad, Adeline; Evagelidis, Alexandra; Luo, Yishan; Goepp, Julie; Ferraro, Pasquale; Roméo, Philippe; Trebak, Mohamed; Wiseman, Paul W; Thomas, David Y; Hanrahan, John W

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

化学遗传筛选发现石胆酸是一种抗衰老化合物,它通过调节管家长寿保证过程,以不依赖于 TOR 的方式延长酵母的寿命

Goldberg Alexander A, Richard Vincent R, Kyryakov Pavlo, Bourque Simon D, Beach Adam, Burstein Michelle T, Glebov Anastasia, Koupaki Olivia, Boukh-Viner Tatiana, Gregg Christopher, Juneau Mylène, English Ann M, Thomas David Y, Titorenko Vladimir I