日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

对克氏锥虫蛋白酶体的药理学和结构理解为开发位点特异性抑制剂提供了关键见解

Thomas C Eadsforth, Leah S Torrie, Paul Rowland, Emma V Edgar, Lorna M MacLean, Christy Paterson, David A Robinson, Sharon M Shepherd, John Thomas, Michael G Thomas, David W Gray, Vincent L G Postis, Manu De Rycker

Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi

1,5-二氢-2H-苯并[b][1,4]二氮杂卓-2,4(3H)-二酮作为克氏锥虫抑制剂的构效关系

Thomas, Michael G; Dunne, Joanne; Dodd, Peter G; D'Oria, Emiliana; Frame, Laura; Garcia-Perez, Adolfo; McGonagle, Kate; Manzano, Pilar; MacLean, Lorna; Paterson, Christy; Riley, Jennifer; Thomas, John; Torrie, Leah S; Wrobel, Karolina; Read, Kevin D; Marco, Maria; De Rycker, Manu

Uncovering the substrate of olefin synthase loading domains in cyanobacteria Picosynechococcus sp. strain PCC 7002

揭示蓝藻 Picosynechococcus sp. PCC 7002 菌株中烯烃合酶装载结构域的底物

Yñigez-Gutierrez, Audrey E; Conley, Erin; Thomas, Michael G; Pfleger, Brian F

The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode egg hatching.

Xenorhabdus nematophila LrhA 转录调节因子调节 γ-酮-N-酰基酰胺的产生,对互利共生宿主线虫卵孵化具有抑制活性

Lam Yick Chong, Hamchand Randy, Mucci Nicholas C, Kauffman Sarah J, Dudkina Natavan, Reagle Emily V, Casanova-Torres Ángel M, DeCuyper Jessica, Chen Haiwei, Song Deguang, Thomas Michael G, Palm Noah W, Goodrich-Blair Heidi, Crawford Jason M

Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora

代谢组学和基因组学助力发现海洋微单孢菌中的一类新型非核糖体肽金属载体

Wu, Qihao; Bell, Bailey A; Yan, Jia-Xuan; Chevrette, Marc G; Brittin, Nathan J; Zhu, Yanlong; Chanana, Shaurya; Maity, Mitasree; Braun, Doug R; Wheaton, Amelia M; Guzei, Ilia A; Ge, Ying; Rajski, Scott R; Thomas, Michael G; Bugni, Tim S

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

基于结构的锥虫蛋白酶体抑制剂哒嗪酮系列的设计与合成

Thomas, Michael G; McGonagle, Kate; Rowland, Paul; Robinson, David A; Dodd, Peter G; Camino-Díaz, Isabel; Campbell, Lorna; Cantizani, Juan; Castañeda, Pablo; Conn, Daniel; Craggs, Peter D; Edwards, Darren; Ferguson, Liam; Fosberry, Andrew; Frame, Laura; Goswami, Panchali; Hu, Xiao; Korczynska, Justyna; MacLean, Lorna; Martin, Julio; Mutter, Nicole; Osuna-Cabello, Maria; Paterson, Christy; Peña, Imanol; Pinto, Erika G; Pont, Caterina; Riley, Jennifer; Shishikura, Yoko; Simeons, Frederick R C; Stojanovski, Laste; Thomas, John; Wrobel, Karolina; Young, Robert J; Zmuda, Filip; Zuccotto, Fabio; Read, Kevin D; Gilbert, Ian H; Marco, Maria; Miles, Timothy J; Manzano, Pilar; De Rycker, Manu

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

重新定位二氨基噻唑系列化合物,证实其靶向细胞周期蛋白依赖性激酶CRK12,可用于治疗非洲动物锥虫病

Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease

鉴定和开发一系列二取代哌嗪类化合物用于治疗恰加斯病

McGonagle, Kate; Tarver, Gary J; Cantizani, Juan; Cotillo, Ignacio; Dodd, Peter G; Ferguson, Liam; Gilbert, Ian H; Marco, Maria; Miles, Tim; Naylor, Claire; Osuna-Cabello, Maria; Paterson, Christy; Read, Kevin D; Pinto, Erika G; Riley, Jennifer; Scullion, Paul; Shishikura, Yoko; Simeons, Frederick; Stojanovski, Laste; Svensen, Nina; Thomas, John; Wyatt, Paul G; Manzano, Pilar; De Rycker, Manu; Thomas, Michael G

Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived Pseudonocardia sp. Bacterium

基因组挖掘和代谢组学揭示了假诺卡林:一种来自海洋来源假诺卡氏菌属细菌的含5-氨基水杨酸的铁载体

Zhang, Fan; Ramos Alvarenga, René F; Throckmorton, Kurt; Chanana, Shaurya; Braun, Doug R; Fossen, Jen; Zhao, Miao; McCrone, Sue; Harper, Mary Kay; Rajski, Scott R; Rose, Warren E; Andes, David R; Thomas, Michael G; Bugni, Tim S

Demographic trends in the incidence of malignant appendiceal tumours in England between 1995 and 2016: Population-based analysis

1995年至2016年英格兰恶性阑尾肿瘤发病率的人口统计学趋势:基于人群的分析

Orchard, Philippa; Preece, Ryan; Thomas, Michael G; Dixon, Steven W; Wong, Newton A C S; Chambers, Adam C; Messenger, David E