日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF

整合系统生物学指出,线粒体功能和代谢紊乱是导致射血分数保留型心力衰竭 (HFpEF) 的关键因素。

Andrew A Gibb ,Kyle LaPenna ,Ryan B Gaspar ,Nadina R Latchman ,Yinfei Tan ,Carmen Choya-Foces ,Jake E Doiron ,Zhen Li ,Huijing Xia ,Michael P Lazaropoulos ,Mariell Conwell ,Thomas E Sharp 3rd ,Traci T Goodchild ,David J Lefer ,John W Elrod

Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction

对于射血分数保留的心脏代谢性心力衰竭患者,口服 H2S 供体的辅助治疗可提供比 SGLT2 抑制更多的治疗益处

Jake E Doiron, Huijing Xia, Xiaoman Yu, Alexandra R Nevins, Kyle B LaPenna, Thomas E Sharp 3rd, Traci T Goodchild, Timothy D Allerton, Mona Elgazzaz, Eric Lazartigues, Sanjiv J Shah, Zhen Li, David J Lefer

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)

综合系统生物学发现,线粒体功能和代谢紊乱是射血分数保留型心力衰竭 (HFpEF) 的主要诱因

Andrew A Gibb, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Carmen Choya-Foces, Jake E Doiron, Zhen Li, Huijing Xia, Michael P Lazaropoulos, Mariell Conwell, Thomas E Sharp 3rd, Traci T Goodchild, David J Lefer, John W Elrod

Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

内皮细胞胱硫醚γ-裂解酶表达水平调节运动能力、血管功能和心肌缺血再灌注损伤

Huijing Xia, Zhen Li, Thomas E Sharp 3rd, David J Polhemus, Jean Carnal, Karl H Moles, Ya-Xiong Tao, John Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, David J Lefer

Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction

皮质骨干细胞治疗可减少心肌梗死后的细胞凋亡

Alexander R H Hobby, Thomas E Sharp 3rd, Remus M Berretta, Giulia Borghetti, Eric Feldsott, Sadia Mohsin, Steven R Houser

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

硫化氢减弱肾素-血管紧张素和醛固酮病理信号以保护肾功能并提高心力衰竭患者的运动耐受性

Zhen Li, Chelsea L Organ, Jianming Kang, David J Polhemus, Rishi K Trivedi, Thomas E Sharp 3rd, Jack S Jenkins, Ya-Xiong Tao, Ming Xian, David J Lefer

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure

新型成纤维细胞活化抑制剂可减轻左心室重塑并维持心力衰竭患者的心脏功能

Jessica M Bradley, Pablo Spaletra, Zhen Li, Thomas E Sharp 3rd, Traci T Goodchild, Laura G Corral, Leah Fung, Kyle W H Chan, Robert W Sullivan, Cathy A Swindlehurst, David J Lefer

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

使用 Ruboxistaurin 抑制蛋白激酶 C 可增强猪心力衰竭模型的收缩力并减小心脏大小,降低射血分数

Thomas E Sharp 3rd, Hajime Kubo, Remus M Berretta, Timothy Starosta, Markus Wallner, Giana J Schena, Alexander R Hobby, Daohai Yu, Danielle M Trappanese, Jon C George, Jeffery D Molkentin, Steven R Houser