日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding

谷氨酰环化酶对细胞表面蛋白CD47和TRP1的焦谷氨酰化作用调节治疗性抗体的结合

Anneloes van der Plas-van Duijn ,Levi M T Winkelman ,Claire Lensen ,Maaike van Duivendijk ,Ian Derksen ,Jacqueline M F van Veenendaal ,Gaby Schaap ,Marjolein Sluijter ,Tim J B van Groningen ,Remco van Doorn ,Thorbald van Hall ,Roderick C Slieker ,Thomas H Sharp ,Joost B Beltman ,Kaspar Bresser ,Ferenc A Scheeren

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

封装 siRNA 的液晶倒置脂质相增强脂质纳米颗粒介导的转染

Roy Pattipeiluhu, Ye Zeng, Marco M R M Hendrix, Ilja K Voets, Alexander Kros, Thomas H Sharp

Germline variant affecting p53β isoforms predisposes to familial cancer

影响 p53β 亚型的生殖细胞变异会导致家族性癌症

Stephanie A Schubert, Dina Ruano, Sebastien M Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M Pinto, Mar Rodríguez-Girondo, Daniela Q C M Barge-Schaapveld, Maartje Nielsen, Bernadette P M van Nesselrooij, Arjen R Mensenkamp, Monique E van Leerdam, Thomas H Sharp, Hans Morreau, Jean-Chri

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

使用结合局部抗原和内源性补体调节剂的双特异性抗体进行靶向补体抑制

Haiyu Wang #, Fleur S van de Bovenkamp #, Douwe J Dijkstra, Leoni Abendstein, Nicole V Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A Gelderman, Timon Damelang, Gestur Vidarsson, Anna M Blom, Elena Domínguez-Vega, Paul W H I Parren, Thomas H Sharp, Leendert A Trouw

Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system

针对先天免疫系统 C1 的肽基补体调节剂的选择和表征

Sebastiaan M W R Hamers, Leoni Abendstein, Aimee L Boyle, Seino A K Jongkees, Thomas H Sharp

Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation

设计激动剂双特异性抗体来研究距离对表面介导补体激活的影响

Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

补体被升高的 IgG3 六聚体平台激活,并将 C4b 沉积到不同的抗体结构域上

Leoni Abendstein, Douwe J Dijkstra, Rayman T N Tjokrodirijo, Peter A van Veelen, Leendert A Trouw, Paul J Hensbergen, Thomas H Sharp

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

恶性疟原虫已经进化出多种劫持人类免疫球蛋白 M 的机制

Chenggong Ji #, Hao Shen #, Chen Su, Yaxin Li, Shihua Chen, Thomas H Sharp, Junyu Xiao

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

人类抗 C1q 自身抗体与固相 C1q 特异性结合,增强吞噬作用,但不增强补体活化

Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S M Kramer, Linda M Slot, Jan W Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan H M Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul W H I Parren, Leendert A Trouw

Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

替代性多聚腺苷酸化利用导致肌肉老化模型中的核糖体组装和 mRNA 翻译缺陷

Hailiang Mei, Jasper Boom, Salma El Abdellaoui, Kotb Abdelmohsen, Rachel Munk, Jennifer L Martindale, Susan Kloet, Szymone M Kielbasa, Thomas H Sharp, Myriam Gorospe, Vered Raz