Thomas McFall相关文献与解析，生知库 | 链接生命科学的每一步

Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach

使用系统生化方法鉴定 EGFR 抑制剂敏感性的 RAS 突变生物标志物

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2021.110096

Thomas McFall, Edward C Stites

Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

辨别 KRAS G13D 结直肠癌对 EGFR 抑制剂敏感性的候选机制

期刊:Cell Communication and Signaling

影响因子:8.2

doi:10.1186/s12964-020-00645-3

Thomas McFall, Noah K Schomburg, Kent L Rossman, Edward C Stites

A systems mechanism for KRAS mutant allele-specific responses to targeted therapy

KRAS 突变等位基因特异性靶向治疗反应的系统机制

期刊:Science Signaling

影响因子:

doi:10.1126/scisignal.aaw8288

Thomas McFall, Jolene K Diedrich, Meron Mengistu, Stacy L Littlechild, Kendra V Paskvan, Laura Sisk-Hackworth, James J Moresco, Andrey S Shaw, Edward C Stites

信号转导

发表日期：2019

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Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer

针对前列腺癌谱系中雄激素受体功能的肿瘤选择性破坏策略

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-18-0982

Rayna Rosati ,Lisa Polin ,Charles Ducker ,Jing Li ,Xun Bao ,Dakshnamurthy Selvakumar ,Seongho Kim ,Besa Xhabija ,Martha Larsen ,Thomas McFall ,Yanfang Huang ,Benjamin L Kidder ,Andrew Fribley ,Janice Saxton ,Hiroki Kakuta ,Peter Shaw ,Manohar Ratnam

Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen

孕酮受体 A 抑制雌激素对关键 microRNA 的调控，促进管腔乳腺癌的侵袭和转移

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M117.812438

Thomas McFall, Brooke McKnight, Rayna Rosati, Seongho Kim, Yanfang Huang, Nerissa Viola-Villegas, Manohar Ratnam

Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

地塞米松慢性诱导 p27Kip1 导致过度表达糖皮质激素受体的肺腺癌细胞出现衰老表型和永久性细胞周期阻滞

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-018-34475-8

Mugdha Patki, Thomas McFall, Rayna Rosati, Yanfang Huang, Agnes Malysa, Lisa Polin, Abigail Fielder, Mike R Wilson, Fulvio Lonardo, Jessica Back, Jing Li, Larry H Matherly, Gerold Bepler, Manohar Ratnam

The Amino-terminal Domain of the Androgen Receptor Co-opts Extracellular Signal-regulated Kinase (ERK) Docking Sites in ELK1 Protein to Induce Sustained Gene Activation That Supports Prostate Cancer Cell Growth

雄激素受体的氨基末端结构域与 ELK1 蛋白中的细胞外信号调节激酶 (ERK) 对接位点协同作用，诱导持续的基因激活，支持前列腺癌细胞的生长

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M116.745596

Rayna Rosati, Mugdha Patki, Venkatesh Chari, Selvakumar Dakshnamurthy, Thomas McFall, Janice Saxton, Benjamin L Kidder, Peter E Shaw, Manohar Ratnam

Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells

具有组蛋白去乙酰化酶抑制剂活性的混合恩杂鲁胺衍生物可降低热休克蛋白 90 和雄激素受体水平并抑制恩杂鲁胺耐药 C4-2 前列腺癌细胞的活力

期刊:Molecular Pharmacology

影响因子:3.2

doi:10.1124/mol.116.103416

Rayna Rosati, Bailing Chen, Mugdha Patki, Thomas McFall, Siyu Ou, Elisabeth Heath, Manohar Ratnam, Zhihui Qin

Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges

孕酮受体短同工酶在绝经前和绝经后雌激素和孕酮水平下对乳腺癌细胞侵袭性的作用

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.5082

Thomas McFall, Mugdha Patki, Rayna Rosati, Manohar Ratnam

Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP

同时靶向 KRAS G12C 和 EGFR 可降低突变型和野生型 RAS-GTP

Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach

使用系统生化方法鉴定 EGFR 抑制剂敏感性的 RAS 突变生物标志物

Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

辨别 KRAS G13D 结直肠癌对 EGFR 抑制剂敏感性的候选机制

A systems mechanism for KRAS mutant allele-specific responses to targeted therapy

KRAS 突变等位基因特异性靶向治疗反应的系统机制

Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer

针对前列腺癌谱系中雄激素受体功能的肿瘤选择性破坏策略

Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen

孕酮受体 A 抑制雌激素对关键 microRNA 的调控，促进管腔乳腺癌的侵袭和转移

Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

地塞米松慢性诱导 p27Kip1 导致过度表达糖皮质激素受体的肺腺癌细胞出现衰老表型和永久性细胞周期阻滞

The Amino-terminal Domain of the Androgen Receptor Co-opts Extracellular Signal-regulated Kinase (ERK) Docking Sites in ELK1 Protein to Induce Sustained Gene Activation That Supports Prostate Cancer Cell Growth

雄激素受体的氨基末端结构域与 ELK1 蛋白中的细胞外信号调节激酶 (ERK) 对接位点协同作用，诱导持续的基因激活，支持前列腺癌细胞的生长

Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells

具有组蛋白去乙酰化酶抑制剂活性的混合恩杂鲁胺衍生物可降低热休克蛋白 90 和雄激素受体水平并抑制恩杂鲁胺耐药 C4-2 前列腺癌细胞的活力

Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges

孕酮受体短同工酶在绝经前和绝经后雌激素和孕酮水平下对乳腺癌细胞侵袭性的作用