日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells

从头生成的NPM-ALK融合基因重现了ALK阳性间变性大细胞淋巴瘤(ALCL)发病机制的多效性表型,并揭示了ROR2受体是肿瘤细胞的靶点。

Loélia Babin # ,Alice Darchen # ,Elie Robert ,Zakia Aid ,Rosalie Borry ,Claire Soudais ,Marion Piganeau ,Anne De Cian ,Carine Giovannangeli ,Olivia Bawa ,Charlotte Rigaud ,Jean-Yves Scoazec ,Lucile Couronné ,Layla Veleanu ,Agata Cieslak ,Vahid Asnafi ,David Sibon ,Laurence Lamant ,Fabienne Meggetto ,Thomas Mercher ,Erika Brunet

SPEN integrates transcriptional and epigenetic control of X-inactivation

SPEN 整合了 X 失活的转录和表观遗传控制

François Dossin, Inês Pinheiro #, Jan J Żylicz #, Julia Roensch, Samuel Collombet, Agnès Le Saux, Tomasz Chelmicki, Mikaël Attia, Varun Kapoor, Ye Zhan, Florent Dingli, Damarys Loew, Thomas Mercher, Job Dekker, Edith Heard

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

核相互作用 SET 结构域蛋白 1 失活会损害 GATA1 调节的红细胞分化并导致红白血病

Katharina Leonards #, Marwa Almosailleakh #, Samantha Tauchmann #, Frederik Otzen Bagger #, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H F M Peters, Thomas Mercher, Juerg Schwaller

AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes

AIF 损失导致造血失调,并揭示骨髓细胞和胸腺细胞中不同的适应性代谢反应

Lauriane Cabon, Audrey Bertaux, Marie-Noëlle Brunelle-Navas, Ivan Nemazanyy, Laurianne Scourzic, Laure Delavallée, Laura Vela, Mathieu Baritaud, Sandrine Bouchet, Cécile Lopez, Vu Quang Van, Kevin Garbin, Danielle Chateau, Françoise Gilard, Marika Sarfati, Thomas Mercher, Olivier A Bernard, Santos A

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

21 号染色体部分三体性导致小鼠模型中 JAK3 激活突变诱发的 T 细胞恶性肿瘤

Paola Rivera-Munoz, Anouchka P Laurent, Aurelie Siret, Cecile K Lopez, Cathy Ignacimouttou, Melanie G Cornejo, Olivia Bawa, Philippe Rameau, Olivier A Bernard, Philippe Dessen, Gary D Gilliland, Thomas Mercher, Sébastien Malinge

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

Ikaros 通过与 GATA-1 和 NOTCH 信号的功能性相互作用抑制巨核细胞生成

Sébastien Malinge, Clarisse Thiollier, Timothy M Chlon, Louis C Doré, Lauren Diebold, Olivier Bluteau, Vinciane Mabialah, William Vainchenker, Philippe Dessen, Susan Winandy, Thomas Mercher, John D Crispino

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

TET2 和 TET3 通过 OGT 和 SET1/COMPASS 调节 GlcNAc 糖基化和 H3K4 甲基化

Rachel Deplus, Benjamin Delatte, Marie K Schwinn, Matthieu Defrance, Jacqui Méndez, Nancy Murphy, Mark A Dawson, Michael Volkmar, Pascale Putmans, Emilie Calonne, Alan H Shih, Ross L Levine, Olivier Bernard, Thomas Mercher, Eric Solary, Marjeta Urh, Danette L Daniels, François Fuks

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

小鼠巨核细胞谱系形成过程中 NOTCH 和 AKT 信号之间的串扰

Melanie G Cornejo, Vinciane Mabialah, Stephen M Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K Lopez, Paola Rivera-Muñoz, Philippe Rameau, Zuzana Tothova, Jon C Aster, Ronald A DePinho, David T Scadden, D Gary Gilliland, Thomas Mercher

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

Cdx4 对于小鼠成体造血干细胞而言并非必需,但可促进 MLL-AF9 介导的白血病发生

Sumin Koo, Brian J Huntly, Yuan Wang, Jing Chen, Kristina Brumme, Brian Ball, Shannon L McKinney-Freeman, Akiko Yabuuchi, Claudia Scholl, Dimple Bansal, Leonard I Zon, Stefan Fröhling, George Q Daley, D Gary Gilliland, Thomas Mercher

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

组成性JAK3激活在小鼠骨髓移植模型中诱发淋巴增生综合征

Melanie G Cornejo, Michael G Kharas, Miriam B Werneck, Séverine Le Bras, Sandra A Moore, Brian Ball, Marie Beylot-Barry, Scott J Rodig, Jon C Aster, Benjamin H Lee, Harvey Cantor, Jean-Philippe Merlio, D Gary Gilliland, Thomas Mercher