日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The impact of introducing meningococcal C/ACWY booster vaccination among adolescents in Germany: a dynamic transmission modelling study

在德国青少年中引入脑膜炎球菌C/ACWY加强疫苗接种的影响:一项动态传播模型研究

Günther, Felix; Reinacher, Ulrich; Chisholm, Sarah; Griskaitis, Matas; Höhle, Michael; Scholz, Stefan; Schönfeld, Viktoria; Wichmann, Ole; Harder, Thomas; Sandmann, Frank G

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

早期干预抗Aβ免疫疗法可减轻小胶质细胞活化,而不会导致残余斑块处的细胞耗竭。

Lis de Weerd ,Selina Hummel ,Stephan A Müller ,Iñaki Paris ,Thomas Sandmann ,Marie Eichholtz ,Robin Gröger ,Amelie L Englert ,Stephan Wagner ,Connie Ha ,Sonnet S Davis ,Valerie Warkins ,Dan Xia ,Brigitte Nuscher ,Anna Berghofer ,Marvin Reich ,Astrid F Feiten ,Kai Schlepckow ,Michael Willem ,Stefan F Lichtenthaler ,Joseph W Lewcock ,Kathryn M Monroe ,Matthias Brendel ,Christian Haass

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Nathalie Khoury,Michelle E Pizzo,Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha,Gabrielly L De Melo,Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow,Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker,Holly Kane,Amy Leung,Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

Effectiveness and efficiency of immunisation strategies to prevent RSV among infants and older adults in Germany: a modelling study

德国婴幼儿和老年人呼吸道合胞病毒(RSV)免疫接种策略的有效性和效率:一项建模研究

Krauer, Fabienne; Guenther, Felix; Treskova-Schwarzbach, Marina; Schoenfeld, Viktoria; Koltai, Mihaly; Jit, Mark; Hodgson, David; Schneider, Udo; Wichmann, Ole; Harder, Thomas; Sandmann, Frank G; Flasche, Stefan

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

阿尔茨海默病相关的 PLCγ2 是 TREM2 功能和人类小胶质细胞炎症反应所需的信号传导节点

Benjamin J Andreone #, Laralynne Przybyla #, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcock

SUPT4H1 Depletion Leads to a Global Reduction in RNA

SUPT4H1 耗竭导致 RNA 整体减少

Adam Naguib, Thomas Sandmann, Fei Yi, Ryan J Watts, Joseph W Lewcock, William E Dowdle

A genetic interaction map of cell cycle regulators

细胞周期调节剂的遗传相互作用图

Maximilian Billmann, Thomas Horn, Bernd Fischer, Thomas Sandmann, Wolfgang Huber, Michael Boutros