日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing

通过蛋白水解加工在囊泡内和细胞外 pH 条件下产生的致密核心分泌囊泡 (DCSV) 的差异神经肽组

Zhenze Jiang, Christopher B Lietz, Sonia Podvin, Michael C Yoon, Thomas Toneff, Vivian Hook, Anthony J O'Donoghue

Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles

磷酸化肽组学揭示致密核心分泌囊泡中神经肽的差异磷酸化状态和新型 SxE 磷酸基序

Christopher B Lietz, Thomas Toneff, Charles Mosier, Sonia Podvin, Anthony J O'Donoghue, Vivian Hook

Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic

脑焦谷氨酸淀粉样蛋白-β由组织蛋白酶B产生,并被半胱氨酸蛋白酶抑制剂E64d减少,代表一种潜在的阿尔茨海默病治疗方法

Gregory Hook, Jin Yu, Thomas Toneff, Mark Kindy, Vivian Hook

Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters

β-淀粉样肽与神经肽和儿茶酚胺神经递质一起进行受调控的共同分泌

Thomas Toneff, Lydiane Funkelstein, Charles Mosier, Armen Abagyan, Michael Ziegler, Vivian Hook

Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters

人类组织蛋白酶 V 蛋白酶参与脑啡肽和 NPY 神经肽神经递质的产生

Lydiane Funkelstein, W Douglas Lu, Britta Koch, Charles Mosier, Thomas Toneff, Laurent Taupenot, Daniel T O'Connor, Thomas Reinheckel, Christoph Peters, Vivian Hook

Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin

人类垂体含有双重蛋白酶 L 和激素原转化酶加工途径成分,参与将 POMC 转化为肽类激素 ACTH、α-MSH 和 β-内啡肽

Vivian Hook, Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Shin-Rong Hwang

Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression

蛋白酶 L 在产生肽类激素 ACTH、β-内啡肽和 α-MSH 方面发挥着重要作用,蛋白酶基因敲除和表达就是例证

Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Shin-Rong Hwang, Felix Beuschlein, Urs D Lichtenauer, Thomas Reinheckel, Christoph Peters, Vivian Hook