日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

小鼠酸性哺乳动物几丁质酶的配体结合和pH特异性酶活性的结构表征

Díaz, Roberto Efraín; Ecker, Andrew K; Correy, Galen J; Asthana, Pooja; Young, Iris D; Faust, Bryan; Thompson, Michael C; Seiple, Ian B; Van Dyken, Steven; Locksley, Richard M; Fraser, James S

Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

利用温度跃变X射线晶体学技术以高空间分辨率绘制蛋白质动力学图谱

Wolff, Alexander M; Nango, Eriko; Young, Iris D; Brewster, Aaron S; Kubo, Minoru; Nomura, Takashi; Sugahara, Michihiro; Owada, Shigeki; Barad, Benjamin A; Ito, Kazutaka; Bhowmick, Asmit; Carbajo, Sergio; Hino, Tomoya; Holton, James M; Im, Dohyun; O'Riordan, Lee J; Tanaka, Tomoyuki; Tanaka, Rie; Sierra, Raymond G; Yumoto, Fumiaki; Tono, Kensuke; Iwata, So; Sauter, Nicholas K; Fraser, James S; Thompson, Michael C

Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography

利用高分辨率XFEL晶体学观察催化过程中酶复合物的变化

Smith, Nathan; Dasgupta, Medhanjali; Wych, David C; Dolamore, Cole; Sierra, Raymond G; Lisova, Stella; Marchany-Rivera, Darya; Cohen, Aina E; Boutet, Sébastien; Hunter, Mark S; Kupitz, Christopher; Poitevin, Frédéric; Moss, Frank R 3rd; Brewster, Aaron S; Sauter, Nicholas K; Young, Iris D; Wolff, Alexander M; Tiwari, Virendra K; Kumar, Nivesh; Berkowitz, David B; Hadt, Ryan G; Thompson, Michael C; Follmer, Alec H; Wall, Michael E; Wilson, Mark A

Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling

利用晶体学增强构象采样设计高效人工酶

Rakotoharisoa, Rojo V; Seifinoferest, Behnoush; Zarifi, Niayesh; Miller, Jack D M; Rodriguez, Joshua M; Thompson, Michael C; Chica, Roberto A

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

室温下中子和X射线衍射揭示SARS-CoV-2 NSP3宏结构域的催化和配体结合机制

Correy, Galen J; Kneller, Daniel W; Phillips, Gwyndalyn; Pant, Swati; Russi, Silvia; Cohen, Aina E; Meigs, George; Holton, James M; Gahbauer, Stefan; Thompson, Michael C; Ashworth, Alan; Coates, Leighton; Kovalevsky, Andrey; Meilleur, Flora; Fraser, James S

Accurate positioning of functional residues with robotics-inspired computational protein design

利用受机器人启发的计算蛋白质设计实现功能残基的精确定位

Krivacic, Cody; Kundert, Kale; Pan, Xingjie; Pache, Roland A; Liu, Lin; Conchúir, Shane O; Jeliazkov, Jeliazko R; Gray, Jeffrey J; Thompson, Michael C; Fraser, James S; Kortemme, Tanja

Generation of bright monomeric red fluorescent proteins via computational design of enhanced chromophore packing.

通过计算机设计增强发色团堆积,生成明亮的单体红色荧光蛋白

Legault Sandrine, Fraser-Halberg Derek P, McAnelly Ralph L, Eason Matthew G, Thompson Michael C, Chica Roberto A

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

一种超强效合成纳米抗体通过稳定非活性刺突蛋白来中和SARS-CoV-2病毒。

Schoof, Michael; Faust, Bryan; Saunders, Reuben A; Sangwan, Smriti; Rezelj, Veronica; Hoppe, Nick; Boone, Morgane; Billesbølle, Christian B; Puchades, Cristina; Azumaya, Caleigh M; Kratochvil, Huong T; Zimanyi, Marcell; Deshpande, Ishan; Liang, Jiahao; Dickinson, Sasha; Nguyen, Henry C; Chio, Cynthia M; Merz, Gregory E; Thompson, Michael C; Diwanji, Devan; Schaefer, Kaitlin; Anand, Aditya A; Dobzinski, Niv; Zha, Beth Shoshana; Simoneau, Camille R; Leon, Kristoffer; White, Kris M; Chio, Un Seng; Gupta, Meghna; Jin, Mingliang; Li, Fei; Liu, Yanxin; Zhang, Kaihua; Bulkley, David; Sun, Ming; Smith, Amber M; Rizo, Alexandrea N; Moss, Frank; Brilot, Axel F; Pourmal, Sergei; Trenker, Raphael; Pospiech, Thomas; Gupta, Sayan; Barsi-Rhyne, Benjamin; Belyy, Vladislav; Barile-Hill, Andrew W; Nock, Silke; Liu, Yuwei; Krogan, Nevan J; Ralston, Corie Y; Swaney, Danielle L; García-Sastre, Adolfo; Ott, Melanie; Vignuzzi, Marco; Walter, Peter; Manglik, Aashish

Expanding the space of protein geometries by computational design of de novo fold families

通过计算设计从头折叠家族来扩展蛋白质几何空间

Pan, Xingjie; Thompson, Michael C; Zhang, Yang; Liu, Lin; Fraser, James S; Kelly, Mark J S; Kortemme, Tanja

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico

基于集合的酶设计可以在计算机模拟中重现实验室定向进化的效果。

Broom, Aron; Rakotoharisoa, Rojo V; Thompson, Michael C; Zarifi, Niayesh; Nguyen, Erin; Mukhametzhanov, Nurzhan; Liu, Lin; Fraser, James S; Chica, Roberto A