日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates

早期暴露于母体胰岛素抵抗会对幼年非人灵长类动物的肝脏非酒精性脂肪性肝病产生持续影响。

Thorn, Stephanie R; Baquero, Karalee C; Newsom, Sean A; El Kasmi, Karim C; Bergman, Bryan C; Shulman, Gerald I; Grove, Kevin L; Friedman, Jacob E

A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia

胰岛素生理性升高可抑制持续低血糖胎羊肌肉特异性泛素连接酶基因的激活

Brown, Laura D; Thorn, Stephanie R; O'Meara, Meghan C; Lavezzi, Jinny R; Rozance, Paul J

Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin

胎羊宫内生长受限时,肝脏葡萄糖生成增加,而胰岛素无法抑制这种增加。

Thorn, Stephanie R; Brown, Laura D; Rozance, Paul J; Hay, William W Jr; Friedman, Jacob E

Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep

增加氨基酸供应可增强葡萄糖刺激的胰岛素分泌,但不会增加胎羊的β细胞数量。

Gadhia, Monika M; Maliszewski, Anne M; O'Meara, Meghan C; Thorn, Stephanie R; Lavezzi, Jinny R; Limesand, Sean W; Hay, William W Jr; Brown, Laura D; Rozance, Paul J

Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply

在长期葡萄糖供应不足的胎羊中,即使胎儿胰岛素浓度升高一周,也未能改善胰岛素分泌或β细胞数量。

Lavezzi, Jinny R; Thorn, Stephanie R; O'Meara, Meghan C; LoTurco, Dan; Brown, Laura D; Hay, William W Jr; Rozance, Paul J

Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques.

围产期接触高脂肪饮食与一岁雄性日本猕猴肝脏交感神经支配减少有关

Grant Wilmon F, Nicol Lindsey E, Thorn Stephanie R, Grove Kevin L, Friedman Jacob E, Marks Daniel L

The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes

宫内生长受限表型:胎儿适应及其对成年后胰岛素抵抗和糖尿病的潜在影响

Thorn, Stephanie R; Rozance, Paul J; Brown, Laura D; Hay, William W Jr

Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling

缺乏瘦素依赖性信号转导和转录激活因子3信号的小鼠乳腺导管生长受损

Thorn, Stephanie R; Giesy, Sarah L; Myers, Martin G Jr; Boisclair, Yves R

Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep

慢性妊娠晚期低血糖可上调胎羊肝脏PEPCK,并伴有PGC1α mRNA和磷酸化CREB的增加。

Rozance, Paul J; Limesand, Sean W; Barry, James S; Brown, Laura D; Thorn, Stephanie R; LoTurco, Dan; Regnault, Timothy R H; Friedman, Jacob E; Hay, William W Jr