日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preservation of Human Colonic Stem Cells Requires an ERK Dynamics Checkpoint Mediated by AKT

人类结肠干细胞的保存需要AKT介导的ERK动力学检查点

Riede, Lauren; Borowiec, Alexander; Mallick, Saptarshi; Mallick, Sohini; Chakrabarti, Jayati; Thorne, Curtis Andrew; Pond, Kelvin W

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors

基于细胞的高内涵方法鉴定出SARS-CoV-2中和作用的独特单克隆抗体和PI3K通路抑制剂

Cabel, Carly R; Guzman, Briana A; Alizadeh, Elaheh; Li, Shuaizhi; Holberg, Cameron; Wichaidit, Chonlarat; Cusanovich, Darren A; Paek, Andrew L; Thatcher, Gregory R J; Van Doorslaer, Koenraad; Nargi, Rachel S; Sutton, Rachel E; Suryadevara, Naveenchandra; Crowe, James E Jr; Carnahan, Robert H; Campos, Samuel K; Thorne, Curtis A

Optimization of a Cas12a-Driven Synthetic Gene Regulatory Network System.

Cas12a驱动的合成基因调控网络系统的优化

Kang HyunJin, Fitch John C, Varghese Reeba P, Thorne Curtis A, Cusanovich Darren A

Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signaling.

Dyr726 是一种可穿透血脑屏障的 PI3Kα、III 型受体酪氨酸激酶和 WNT 信号通路抑制剂

Tandon Vasudha, Fistrovich Alessandra, Nogales Joaquina, Ferro Febe, Rokey Samantha N, Cabel Carly, Miller Amy Dunne, Yagel Mary, Duncan Christina, Atmasidha Aditi, Sharma Ira, Wilms Gerrit, Williams Karin, Elliott Richard, Chavez Timothy, Shaw Yeng, McMahon Aidan, Ginn Sean, Basantes L Emilia, Bedard Nathan, Gokhale Vijay, Ellis Nathan, Prescott Alan R, Smith Stuart J, Rahman Ruman, Becker Walter, Read Kevin D, Chalmers Anthony J, Carragher Neil, Masson Glenn R, Montfort William, Thorne Curtis, Hulme Christopher, Banerjee Sourav

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

单细胞分析证实LRP6在APC缺陷细胞的Wnt信号通路中起关键作用

Cabel, Carly R; Alizadeh, Elaheh; Robbins, David J; Ahmed, Yashi; Lee, Ethan; Thorne, Curtis A

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

肠道髓系细胞对微生物的感知控制着癌变和上皮分化

Miyata, Naoteru; Morris, Lindsey L; Chen, Qing; Thorne, Curtis; Singla, Amika; Zhu, Wenhan; Winter, Maria; Melton, Shelby D; Li, Haiying; Sifuentes-Dominguez, Luis; Llano, Ernesto; Huff-Hardy, Kayci; Starokadomskyy, Petro; Lopez, Adam; Reese, Tiffany A; Turer, Emre; Billadeau, Daniel D; Winter, Sebastian E; Burstein, Ezra

FGF21 Is an Exocrine Pancreas Secretagogue

FGF21 是一种外分泌胰腺促分泌剂

Coate, Katie C; Hernandez, Genaro; Thorne, Curtis A; Sun, Shengyi; Le, Thao D V; Vale, Kevin; Kliewer, Steven A; Mangelsdorf, David J

Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs

筛选胚胎通路的小分子抑制剂:有时候你得打破几个鸡蛋

Hang, Brian I; Thorne, Curtis A; Robbins, David J; Huppert, Stacey S; Lee, Laura A; Lee, Ethan

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts

利用非洲爪蟾卵提取物进行Wnt信号通路小分子调节剂的生化筛选

Thorne, Curtis A; Lafleur, Bonnie; Lewis, Michelle; Hanson, Alison J; Jernigan, Kristin K; Weaver, David C; Huppert, Kari A; Chen, Tony W; Wichaidit, Chonlarat; Cselenyi, Christopher S; Tahinci, Emilios; Meyers, Kelly C; Waskow, Emily; Orton, Darren; Salic, Adrian; Lee, Laura A; Robbins, David J; Huppert, Stacey S; Lee, Ethan

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity

Gβγ激活GSK3,促进LRP6介导的β-catenin转录活性

Jernigan, Kristin K; Cselenyi, Christopher S; Thorne, Curtis A; Hanson, Alison J; Tahinci, Emilios; Hajicek, Nicole; Oldham, William M; Lee, Laura A; Hamm, Heidi E; Hepler, John R; Kozasa, Tohru; Linder, Maurine E; Lee, Ethan