日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

IGF-1信号通路减弱对寿命的影响取决于线粒体基因组的稳定性

Shemtov, Sarah J; McGann, Eric; Carrillo, Lucy; Lee, Sangmin; Anson, Herbert; Hwang, Eric; Chung, Claire S; Weinert, Jaye L; Anagnostou, Maria-Eleni; Lai, Guan-Ju D; Verheijen, Bert M; Wan, Junxiang; Vorobyova, Ivetta; Sanchez-Contreras, Monica; Conover, Cheryl A; Thorwald, Max A; Cohen, Pinchas; Kennedy, Scott R; Gout, Jean-François; Haroon, Suraiya; Vermulst, Marc

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

单细胞分析表明,GSM-15606可减轻空气污染引起的炎症并保护海马神经发生。

Shariq, Mohammad; Pan, Wanqing; Chen, Xiran; Xiang, Wang; Godoy-Lugo, Jose; Peng, Lei; Levi, Jonathan N; Ibreyeva, Albina; Shkirkova, Kristina; Nguyen, Wynnie; Sioutas, Constantinos; Mack, William J; Finch, Caleb E; Thorwald, Max A; Bonaguidi, Michael A

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants

化学性质不同的空气污染物诱导与阿尔茨海默病相关的铁死亡和淀粉样蛋白生成特征

Shkirkova, Kristina; Maria, Naomi S Sta; Anson, Herbert; Aghaei, Yashar; Badami, Mohammad Mahdi; Chakhoyan, Ararat; Godoy-Lugo, Jose A; Chung, Claire; Durra, Salma; Tang-Tan, Angela; Zhao, Lifu; Demetriou, Alexandra; Morales, Manuel; Daggupati, Sindhu; Bent, Isabella; Park, Hyoungjin; Franklin, Caleb; Chen, Selena; Chahine, Giovanni; Dodds-Lewis, Skyye; Morishita, Masako; Jacobs, Russell E; Gout, Jean-François; Mack, Wendy J; Forman, Henry Jay; Benayoun, Bérénice A; Vermulst, Marc; Cohen, Mitchell D; Campen, Matthew; Sioutas, Constantinos; Mack, William J; Finch, Caleb E; Thorwald, Max A

Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics.

与年龄相关的线粒体 Prdx6 减少会导致肌肉生物能量学失调

Arevalo Jose Adan, Xing Dianna, Leija Roberto Garcia, Thorwald Max A, Moreno-Santillán Diana Daniela, Allen Kaitlin N, Selleghin-Veiga Giovanna, Avalos Heidi C, Utke Eva, Conner Justin L, Brooks George A, Vázquez-Medina José Pablo

Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

在阿尔茨海默病中,铁相关的脂质过氧化作用在脂筏中增强,而铁死亡抑制因子减少,这一现象已通过小鼠螯合实验得到证实。

Thorwald, Max A; Godoy-Lugo, Jose A; Garcia, Gilberto; Silva, Justine; Kim, Minhoo; Christensen, Amy; Mack, Wendy J; Head, Elizabeth; O'Day, Peggy A; Benayoun, Bérénice A; Morgan, Todd E; Pike, Christian J; Higuchi-Sanabria, Ryo; Forman, Henry Jay; Finch, Caleb E

Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

空气污染会降低小鼠大脑皮层突触体中的突触后 PSD-95 和 NMDA 受体亚基

Godoy-Lugo Jose A, Hicks Daniel, Durra Salma, Massey Emma R, Shkirkova Kristina, Sauri Ariel I, Kerstiens Elizabeth, Chen Selena, Zhao Lifu, Sioutas Constantinos, Mack William J, Finch Caleb E, Thorwald Max A

Beyond genes and environment: mapping biological stochasticity in aging

超越基因和环境:绘制衰老过程中的生物随机性图谱

Hruby, Adam J; Garcia, Gilberto; Thorwald, Max A; Finch, Caleb E; Johnson, Joshua; Higuchi-Sanabria, Ryo

Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer's disease mouse model via enhancing neurotrophic and synaptic signaling.

激活肌肉-大脑轴可通过增强神经营养和突触信号传导来改善阿尔茨海默病小鼠模型的神经认知缺陷

Taha Hash Brown, Birnbaum Allison, Matthews Ian, Aceituno Karel, Leon Jocelyne, Thorwald Max, Godoy-Lugo Jose, Cortes Constanza J

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

IGF-1信号通路减弱对寿命的影响取决于线粒体基因组的稳定性

Shemtov, Sarah J; McGann, Eric; Carrillo, Lucy; Lee, Sangmin; Anson, Herbert; Chung, Claire S; Anagnostou, Maria-Eleni; Lai, Guan-Ju D; Verheijen, Bert M; Wan, Junxiang; Vorobyova, Ivetta; Sanchez-Contreras, Monica; Conover, Cheryl A; Thorwald, Max A; Cohen, Pinchas; Kennedy, Scott R; Gout, Jean-François; Haroon, Suraiya; Vermulst, Marc

Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging

黑猩猩和人类的ApoE同种型在刺激神经突分化方面存在差异,这与结构预测相符,并涉及大脑发育和衰老。

Thorwald, Max A; Cacciottolo, Mafalda; Hou, Xiaogang; Morgan, Todd E; Finch, Caleb E