日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment

射血分数保留型心力衰竭中的左心室肥厚和心肌纤维化:机制和治疗

Peikert, Alexander; Fontana, Marianna; Solomon, Scott D; Thum, Thomas

Time- and spatially resolved LNA delivery via thermally controlled SPION technology

通过热控超顺磁性氧化铁纳米颗粒(SPION)技术实现时间和空间分辨的低噪声放大器(LNA)递送

Kenneweg, Franziska; Hempel, Katharina; Höhne, Lukas Philipp Joachim; Dräger, Gerald; Blume, Jonas; Viereck, Thilo; Stohwasser, Anastasia; Groß, Sonja; Büchler, Gwen; Jansen, Karina; Juchem, Malte; Bär, Christian; Pfanne, Angelika; Just, Annette; Thum, Sabrina; Gietz, Anika; Kirschning, Andreas; Thum, Thomas

mRNA-based SARS-CoV-2 vaccines: intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress

基于mRNA的SARS-CoV-2疫苗:编码的刺突蛋白的细胞内加工和聚集是导致心脏细胞应激的机制性因素。

Schreckenberg, Rolf; Woitasky, Nadine; Itani, Nadja; Czech, Laureen; Windhorst, Anita C; Juchem, Malte; Bär, Christian; Thum, Thomas; Ferdinandy, Péter; Schulz, Rainer

Anti-senescence therapies: a new concept to address cardiovascular disease

抗衰老疗法:应对心血管疾病的新理念

Stojanović, Stevan D; Thum, Thomas; Bauersachs, Johann

miRNA discovery to therapy: The field is sufficiently mature to assess the value of miRNA-based therapeutics

从miRNA发现到治疗:该领域已足够成熟,可以评估基于miRNA的疗法的价值。

Baker, Andrew H; Giacca, Mauro; Thum, Thomas

State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases

心力衰竭基因治疗的最新进展和展望。欧洲心脏病学会心力衰竭协会、欧洲心脏病学会心血管基因组学委员会和欧洲心脏病学会心肌及心包疾病工作组的科学声明。

Van Linthout, Sophie; Stellos, Konstantinos; Giacca, Mauro; Bertero, Edoardo; Cannata, Antonio; Carrier, Lucie; Garcia-Pavia, Pablo; Ghigo, Alessandra; González, Arantxa; Haugaa, Kristina H; Imazio, Massimo; Lopes, Luis R; Most, Patrick; Pollesello, Piero; Schunkert, Heribert; Streckfuss-Bömeke, Katrin; Thum, Thomas; Tocchetti, Carlo Gabriele; Tschöpe, Carsten; van der Meer, Peter; van Rooij, Eva; Metra, Marco; Rosano, Giuseppe M C; Heymans, Stephane

Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia.

癌症细胞因子诱导的恶病质通过多种机制损害钙处理机制和肌节组装

Gand Luis Vincens, Lanzuolo Chiara, Li Mugeng, Rosti Valentina, Weber Natalie, Lu Dongchao, Bär Christian, Thum Thomas, Pich Andreas, Kraft Theresia, Amrute-Nayak Mamta, Nayak Arnab

Telomerase modRNA Offers a Novel RNA-Based Approach to Treat Human Pulmonary Fibrosis.

端粒酶修饰RNA为治疗人类肺纤维化提供了一种基于RNA的新方法。

Ye Jia Li, Grieger Klaudia, Lu Dongchao, Brandenberger Christina, Juchem Malte, Jordan Maria, Oehlsen Lea, Zardo Patrick, Werlein Christopher, Hesse Christina, Sewald Katherina, Tretbar Sandy, Thum Thomas, Chatterjee Shambhabi, Bär Christian

A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling

源自兰尼碱受体2基因座的环状RNA调控心脏肥大和钙离子处理。

Pan, Wen; Hunkler, Hannah J; Chatterjee, Shambhabi; Lu, Dongchao; Riedel, Isabelle; Gietz, Anika; Xiao, Ke; Fuchs, Maximilian; Neufeldt, Dimyana; Kraft, Theresia; Huang, Cheng-Kai; Cushman, Sarah; Bührke, Anne; Schmidt, Arne; Mohr, Elisa; Weber, Natalie; Bär, Christian; Thum, Thomas

Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung.

将小分子肾上腺素受体抑制剂卡维地洛重新用于治疗肺纤维化

Jordan Maria, Schmidt Kevin, Fuchs Maximilian, Just Annette, Pfanne Angelika, Willmer Lena, Neubert Lavinia, Werlein Christopher, Zardo Patrick, Pich Andreas, Thum Thomas, Fiedler Jan