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Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy

人类肠道类器官：预测口服药物处置、毒性和疗效的非临床应用

期刊:Pharmacology & Therapeutics

影响因子:12.5

doi:10.1016/j.pharmthera.2025.108879

O'Mahony, Eimear T; Arian, Christopher M; Aryeh, Kayenat S; Wang, Kai; Thummel, Kenneth E; Kelly, Edward J

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity

草酸钙微晶对微重力下肾近端小管上皮细胞基因表达的影响

期刊:NPJ Microgravity

影响因子:4.1

doi:10.1038/s41526-025-00543-3

Jones-Isaac, Kendan; Yeung, Catherine K; Bain, Jacelyn; Lidberg, Kevin; Yang, Jade; Wang, Lu; MacDonald, James; Bammler, Theo; Thummel, Kenneth E; Corn, Megan; Ruiz, Micaela Vela; Countryman, Stefanie; Koenig, Paul; Mann, Henning H; Himmelfarb, Jonathan; Kelly, Edward J

Leveraging RNA-seq deconvolution to improve complex in vitro model characterization

利用RNA-seq反卷积技术改进复杂体外模型表征

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.110510

Hansen, Brad C; Arian, Christopher M; Zeng, Yuting; Takezawa, Meg G; Theberge, Ashleigh B; Faustman, Elaine M; Thummel, Kenneth E; Kelly, Edward J

发表日期：2025

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A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption

肠道反应：应用人肠类器官单层细胞探究北美黄连介导的二甲双胍肠道吸收抑制机制

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1016/j.jpet.2025.103597

Arian, Christopher M; O'Mahony, Eimear T; Manwill, Preston K; Graf, Tyler N; Oberlies, Nicholas H; Cech, Nadja B; Clarke, John D; Smith, Jason G; Paine, Mary F; Kelly, Edward J; Thummel, Kenneth E

The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

二甲双胍与天然产物金印草之间的药代动力学相互作用与二甲双胍剂量相关：一项针对 2 型糖尿病成年患者的三臂交叉研究

期刊:Cts-Clinical and Translational Science

影响因子:2.8

doi:10.1111/cts.70120

Nguyen James T, Arian Christopher M, Tanna Rakshit S, Cherel Maxey G, Layton Matthew E, White John R, Thummel Kenneth E, Paine Mary F

Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme

深入研究 miR-126-5p 对 CYP2A6（主要的尼古丁失活酶）调控的作用

期刊:Pharmacology Research & Perspectives

影响因子:2.3

doi:10.1002/prp2.70149

Gu, Weilong; Langlois, Alec W R; Giratallah, Haidy; Claw, Katrina G; Prasad, Bhagwat; Thummel, Kenneth E; Tyndale, Rachel F

信号转导

发表日期：2025

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Cytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity

细胞色素P450家族4F2和4F11单倍型定位及其与肝脏基因表达和维生素K羟基化活性的关联

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.3c00287

Alade, Ayoade N; Claw, Katrina G; McDonald, Matthew G; Prasad, Bhagwat; Rettie, Allan E; Thummel, Kenneth E

细胞生物学

发表日期：2024

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Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking

识别社会人口学、临床和遗传因素，以帮助阿拉斯加原住民和美洲印第安人成功戒烟

期刊:Nicotine & Tobacco Research

影响因子:3

doi:10.1093/ntr/ntad133

Avey, Jaedon P; Schaefer, Krista R; Noonan, Carolyn J; Trinidad, Susan B; Muller, Clemma J; Claw, Katrina G; Dillard, Denise A; Todd, Michael R; Beans, Julie A; Tyndale, Rachel F; Robinson, Renee F; Thummel, Kenneth E

发表日期：2024

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Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants

对健康成年受试者中细胞色素P450介导的大麻素-药物相互作用的评估

期刊:Clinical Pharmacology & Therapeutics

影响因子:5.5

doi:10.1002/cpt.2973

Bansal, Sumit; Zamarripa, C Austin; Spindle, Tory R; Weerts, Elise M; Thummel, Kenneth E; Vandrey, Ryan; Paine, Mary F; Unadkat, Jashvant D

细胞生物学

发表日期：2023

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Effect of proinflammatory cytokines on intestinal drug transporters in human enteroid monolayers

促炎细胞因子对人肠类器官单层细胞中肠道药物转运蛋白的影响

Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy

人类肠道类器官：预测口服药物处置、毒性和疗效的非临床应用

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity

草酸钙微晶对微重力下肾近端小管上皮细胞基因表达的影响

Leveraging RNA-seq deconvolution to improve complex in vitro model characterization

利用RNA-seq反卷积技术改进复杂体外模型表征

A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption

肠道反应：应用人肠类器官单层细胞探究北美黄连介导的二甲双胍肠道吸收抑制机制

The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

二甲双胍与天然产物金印草之间的药代动力学相互作用与二甲双胍剂量相关：一项针对 2 型糖尿病成年患者的三臂交叉研究

Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme

深入研究 miR-126-5p 对 CYP2A6（主要的尼古丁失活酶）调控的作用

Cytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity

细胞色素P450家族4F2和4F11单倍型定位及其与肝脏基因表达和维生素K羟基化活性的关联

Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking

识别社会人口学、临床和遗传因素，以帮助阿拉斯加原住民和美洲印第安人成功戒烟

Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants

对健康成年受试者中细胞色素P450介导的大麻素-药物相互作用的评估