日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mapping the phenotypic landscape of a transcriptional repressor using deep mutational scanning and growth-based quantitative sequencing

利用深度突变扫描和基于生长的定量测序绘制转录抑制因子的表型图谱

Jansen, Zachary; Le, Xuan; Wei, Qiyao; Kulhanek, Devon L; Alperovich, Nina; Vasilyeva, Olga; Gilmour, Andrew R; Ross, David; Thyer, Ross

Preclinical Evaluation of Synthetic Biology-Driven Engineered Escherichia coli Nissle 1917 as a Living Therapeutic for Sustained L-DOPA Delivery

利用合成生物学方法改造的大肠杆菌 Nissle 1917 作为持续递送左旋多巴的活体疗法的临床前评估

Abdalla, Ahmed; Padhi, Piyush; Bakes, Nicholas; Thyer, Ross; Zenitsky, Gary; Jin, Huajun; Anantharam, Vellareddy; Kanthasamy, Arthi; Ellington, Andrew D; Phillips, Gregory J; Kanthasamy, Anumantha G

A stationary phase-specific bacterial green light sensor for enhancing metabolite production

用于增强代谢物产生的静止期特异性细菌绿光传感器

Lazar, John T; Haller, Daniel J; Ghaddar, Abbas; Kim, Jae J; Yang, Kevin; Castillo-Hair, Sebastián M; Gilmour, Andrew R; Thyer, Ross; Tabor, Jeffrey J

Engineering a Bright Near-Infrared Fluorescent Protein by Screening a Comprehensive Phenotypic Landscape

通过筛选全面的表型图谱来设计一种明亮的近红外荧光蛋白

Kulhanek, Devon L; Wei, Qiyao; Head, Jared; Hellinger, Jessica; Jansen, Zach; Gilmour, Andrew; Segall-Shapiro, Thomas; Brodbelt, Jennifer S; Usama, Syed Muhammad; Thyer, Ross

Directed evolution of L-DOPA sensing and production enables efficient incorporation of an expanded genetic code into proteins

通过定向进化L-DOPA的感知和生产,可以有效地将扩展的遗传密码整合到蛋白质中。

Gilmour, Andrew R; Wei, Qiyao; Wang, Chad; Hellinger, Jessica; Pandarinath, Vidya; d'Oelsnitz, Simon; Powell, Eli; Brodbelt, Jennifer S; Ellington, Andrew D; Thyer, Ross

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation

用于环境红球菌属、戈登氏菌属和诺卡氏菌属的模块化工具包能够实现复杂的代谢调控

Jansen, Zachary; Alameri, Abdulaziz; Wei, Qiyao; Kulhanek, Devon L; Gilmour, Andrew R; Halper, Sean; Schwalm, Nathan D 3rd; Thyer, Ross

Directed Evolution of an Improved Aminoacyl-tRNA Synthetase for Incorporation of L-3,4-Dihydroxyphenylalanine (L-DOPA)

定向进化改良氨酰tRNA合成酶以掺入L-3,4-二羟基苯丙氨酸(L-DOPA)

Thyer, Ross; d'Oelsnitz, Simon; Blevins, Molly S; Klein, Dustin R; Brodbelt, Jennifer S; Ellington, Andrew D

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains.

利用实验室对重编码细菌菌株进行进化,实现了定制硒蛋白的生产

Thyer Ross, Shroff Raghav, Klein Dustin R, d'Oelsnitz Simon, Cotham Victoria C, Byrom Michelle, Brodbelt Jennifer S, Ellington Andrew D

Evolving tRNA(Sec) for efficient canonical incorporation of selenocysteine

进化 tRNA(Sec) 以实现硒代半胱氨酸的高效经典掺入

Thyer, Ross; Robotham, Scott A; Brodbelt, Jennifer S; Ellington, Andrew D