Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion.
可生物降解的靶向聚合物 mRNA 纳米颗粒能够实现体内 CD19 CAR T 细胞的生成,并导致 B 细胞耗竭。
期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adz1722
Jain Manav, Est-Witte Savannah E, Shannon Sydney R, Neshat Sarah Y, Yu Xinjie, Dunham Sydney, Tian Tina, Cheng Leonardo, Harris Jawaun, Konig Maximilian F, Tzeng Stephany Y, Schneck Jonathan P, Green Jordan J