日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Substrate Turnover Dynamics Guide Ketol-Acid Reductoisomerase Redesign for Increased Specific Activity

底物周转动力学指导酮酸还原异构酶的重新设计以提高比活性

Karvelis, Elijah; Swanson, Chloe; Tidor, Bruce

Machine Learning Identifies Chemical Characteristics That Promote Enzyme Catalysis

机器学习识别促进酶催化的化学特性

Bonk, Brian M; Weis, James W; Tidor, Bruce

Rational design of thiolase substrate specificity for metabolic engineering applications

硫解酶底物特异性的合理设计及其在代谢工程中的应用

Brian M Bonk, Yekaterina Tarasova, Michael A Hicks, Bruce Tidor, Kristala L J Prather

Intramolecular Hydrogen Bonding Restricts Gd-Aqua-Ligand Dynamics

分子内氢键限制了Gd-水-配体动力学

Boros, Eszter; Srinivas, Raja; Kim, Hee-Kyung; Raitsimring, Arnold M; Astashkin, Andrei V; Poluektov, Oleg G; Niklas, Jens; Horning, Andrew D; Tidor, Bruce; Caravan, Peter

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

利用时间侧支敏感性研究肿瘤克隆进化

Boyang Zhao, Joseph C Sedlak, Raja Srinivas, Pau Creixell, Justin R Pritchard, Bruce Tidor, Douglas A Lauffenburger, Michael T Hemann

A Fungal-Selective Cytochrome bc(1) Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

一种真菌选择性细胞色素bc(1)抑制剂可削弱真菌毒力并阻止耐药性的产生。

Vincent, Benjamin M; Langlois, Jean-Baptiste; Srinivas, Raja; Lancaster, Alex K; Scherz-Shouval, Ruth; Whitesell, Luke; Tidor, Bruce; Buchwald, Stephen L; Lindquist, Susan

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

电荷中和的超热稳定 Sso7d 支架库中结合位点中芳香族残基的高度富集

Michael W Traxlmayr, Jonathan D Kiefer, Raja R Srinivas, Elisabeth Lobner, Alison W Tisdale, Naveen K Mehta, Nicole J Yang, Bruce Tidor, K Dane Wittrup

Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition

避免耐药性的广谱抑制剂的分子机制和设计原则:从HIV-1蛋白酶抑制中汲取的经验教训

Shen, Yang; Radhakrishnan, Mala L; Tidor, Bruce

Multilevel modeling and value of information in clinical trial decision support

多层次模型和信息在临床试验决策支持中的价值

Cui, Yuanyuan; Murphy, Brendan; Gentilcore, Anastasia; Sharma, Yugal; Minasian, Lori M; Kramer, Barnett S; Coates, Paul M; Gohagan, John K; Klenk, Juergen; Tidor, Bruce

Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration

利用系综枚举法高效计算小分子构型结合熵和自由能变化

Silver, Nathaniel W; King, Bracken M; Nalam, Madhavi N L; Cao, Hong; Ali, Akbar; Kiran Kumar Reddy, G S; Rana, Tariq M; Schiffer, Celia A; Tidor, Bruce