日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural characterization and inhibition of the interaction between ch-TOG and TACC3.

ch-TOG 与 TACC3 相互作用的结构表征和抑制

Shelford James, Burgess Selena G, Rostkova Elena, Richards Mark W, Larocque Gabrielle, Sampson Josephina, Tiede Christian, Fielding Alistair J, Daviter Tina, Tomlinson Darren C, Calabrese Antonio N, Pfuhl Mark, Bayliss Richard, Royle Stephen J

Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer

亲和试剂作为工具分子,可用于调节血小板GPVI-配体相互作用并特异性结合GPVI二聚体。

Xu, Rui-Gang; Tiede, Christian; Calabrese, Antonio N; Cheah, Lih T; Adams, Thomas L; Gauer, Julia S; Hindle, Matthew S; Webb, Beth A; Yates, Daisie M; Slater, Alexandre; Duval, Cédric; Naseem, Khalid M; Herr, Andrew B; Tomlinson, Darren C; Watson, Steve P; Ariëns, Robert A S

Nanoscale Pattern Extraction from Relative Positions of Sparse 3D Localizations

从稀疏三维定位的相对位置提取纳米级图案

Curd, Alistair P; Leng, Joanna; Hughes, Ruth E; Cleasby, Alexa J; Rogers, Brendan; Trinh, Chi H; Baird, Michelle A; Takagi, Yasuharu; Tiede, Christian; Sieben, Christian; Manley, Suliana; Schlichthaerle, Thomas; Jungmann, Ralf; Ries, Jonas; Shroff, Hari; Peckham, Michelle

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk

纤维蛋白原与补体C3的相互作用:降低血栓风险的潜在治疗靶点

King, Rhodri J; Schuett, Katharina; Tiede, Christian; Jankowski, Vera; John, Vicky; Trehan, Abhi; Simmons, Katie; Ponnambalam, Sreenivasan; Storey, Robert F; Fishwick, Colin W G; McPherson, Michael J; Tomlinson, Darren C; Ajjan, Ramzi A

Selective Affimers Recognise the BCL-2 Family Proteins BCL-x(L) and MCL-1 through Noncanonical Structural Motifs*

选择性亲和剂通过非典型结构基序识别 BCL-2 家族蛋白 BCL-x(L) 和 MCL-1*

Miles, Jennifer A; Hobor, Fruzsina; Trinh, Chi H; Taylor, James; Tiede, Christian; Rowell, Philip R; Jackson, Brian R; Nadat, Fatima A; Ramsahye, Pallavi; Kyle, Hannah F; Wicky, Basile I M; Clarke, Jane; Tomlinson, Darren C; Wilson, Andrew J; Edwards, Thomas A

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Affimer蛋白通过竞争性和变构作用方式,以高特异性抑制免疫复合物与FcγRIIIa的结合。

Robinson, James I; Baxter, Euan W; Owen, Robin L; Thomsen, Maren; Tomlinson, Darren C; Waterhouse, Mark P; Win, Stephanie J; Nettleship, Joanne E; Tiede, Christian; Foster, Richard J; Owens, Raymond J; Fishwick, Colin W G; Harris, Sarah A; Goldman, Adrian; McPherson, Michael J; Morgan, Ann W

Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells

用于标记F-肌动蛋白的亲和蛋白:新型亲和试剂,可标记活细胞和固定细胞中的F-肌动蛋白

Lopata, Anna; Hughes, Ruth; Tiede, Christian; Heissler, Sarah M; Sellers, James R; Knight, Peter J; Tomlinson, Darren; Peckham, Michelle

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology

利用Affimer(Adhiron)技术生成SUMO-1和SUMO-2/3介导的蛋白质-蛋白质相互作用的特异性抑制剂

Hughes, David J; Tiede, Christian; Penswick, Natalie; Tang, Anna Ah-San; Trinh, Chi H; Mandal, Upasana; Zajac, Katarzyna Z; Gaule, Thembaninskosi; Howell, Gareth; Edwards, Thomas A; Duan, Jianxin; Feyfant, Eric; McPherson, Michael J; Tomlinson, Darren C; Whitehouse, Adrian