日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo

患者脑水提取物中的 Tau 和淀粉样 β 蛋白同时作用,破坏体内长期增强作用

Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andy Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowan

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain

鉴定阿尔茨海默病患者大脑中的神经毒性交联淀粉样β二聚体

Gunnar Brinkmalm, Wei Hong, Zemin Wang, Wen Liu, Tiernan T O'Malley, Xin Sun, Matthew P Frosch, Dennis J Selkoe, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Dominic M Walsh

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease

评估阿尔茨海默病潜在抗 Aβ 抗体的体外范例

Ming Jin, Brian O'Nuallain, Wei Hong, Justin Boyd, Valentina N Lagomarsino, Tiernan T O'Malley, Wen Liu, Charles R Vanderburg, Matthew P Frosch, Tracy Young-Pearse, Dennis J Selkoe, Dominic M Walsh

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain

可扩散、高生物活性的低聚物是阿尔茨海默病脑中可溶性 Aβ 的关键少数

Wei Hong, Zemin Wang, Wen Liu, Tiernan T O'Malley, Ming Jin, Michael Willem, Christian Haass, Matthew P Frosch, Dominic M Walsh

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

来自阿尔茨海默病iPSC模型的细胞外Aβ和Tau蛋白会破坏突触可塑性

Hu, Neng-Wei; Corbett, Grant T; Moore, Steven; Klyubin, Igor; O'Malley, Tiernan T; Walsh, Dominic M; Livesey, Frederick J; Rowan, Michael J

Production and Use of Recombinant Aβ for Aggregation Studies

重组 Aβ 的产生及其在聚集研究中的应用

Tiernan T O'Malley, Sara Linse, Dominic M Walsh

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

可溶性Aβ寡聚体通过破坏谷氨酸能/GABA能平衡来损害海马长时程增强作用(LTP)。

Lei, Ming; Xu, Huixin; Li, Zhangyuan; Wang, Zemin; O'Malley, Tiernan T; Zhang, Dainan; Walsh, Dominic M; Xu, Pingyi; Selkoe, Dennis J; Li, Shaomin

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer

Aβ42 二聚体的聚集路径和产物与 Aβ42 单体不同

Tiernan T O'Malley, William M Witbold 3rd, Sara Linse, Dominic M Walsh

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

阿尔茨海默病患者脑组织的水相中含有由约4 kDa和约7 kDa的Aβ物种构成的组装体。

Mc Donald, Jessica M; O'Malley, Tiernan T; Liu, Wen; Mably, Alexandra J; Brinkmalm, Gunnar; Portelius, Erik; Wittbold, William M 3rd; Frosch, Matthew P; Walsh, Dominic M

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

一种高灵敏度的新型免疫测定法可特异性检测人脑脊液中低浓度的可溶性Aβ寡聚体。

Yang, Ting; O'Malley, Tiernan T; Kanmert, Daniel; Jerecic, Jasna; Zieske, Lynn R; Zetterberg, Henrik; Hyman, Bradley T; Walsh, Dominic M; Selkoe, Dennis J