日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

视黄酸和 BH3 类似物在 MYC(N) 驱动的胚胎神经系统肿瘤中的协同作用

Till Seiboldt, Constantia Zeiser, Duy Nguyen, Simay Celikyürekli, Sonja Herter, Sara Najafi, Alexandra Stroh-Dege, Chris Meulenbroeks, Norman Mack, Rabia Salem-Altintas, Frank Westermann, Matthias Schlesner, Till Milde, Marcel Kool, Tim Holland-Letz, Meike Vogler, Heike Peterziel, Olaf Witt, Ina Oeh

Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells

联合药物筛选确定了 BCL-XL 与 I 类组蛋白去乙酰化酶抑制剂在 MYC 扩增的髓母细胞瘤细胞中的协同药物相互作用

Simon Zeuner, Johanna Vollmer, Romain Sigaud, Sina Oppermann, Heike Peterziel, Dina ElHarouni, Ina Oehme, Olaf Witt, Till Milde, Jonas Ecker

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

三维基因组图谱分析揭示室管膜瘤亚组特异性染色体构象和肿瘤依赖性基因

Konstantin Okonechnikov #,Aylin Camgöz #,Owen Chapman,Sameena Wani,Donglim Esther Park,Jens-Martin Hübner,Abhijit Chakraborty,Meghana Pagadala,Rosalind Bump,Sahaana Chandran,Katerina Kraft,Rocio Acuna-Hidalgo,Derek Reid,Kristin Sikkink,Monika Mauermann,Edwin F Juarez,Anne Jenseit,James T Robinson,Kristian W Pajtler,Till Milde,Natalie Jäger,Petra Fiesel,Ling Morgan,Sunita Sridhar,Nicole G Coufal,Michael Levy,Denise Malicki,Charlotte Hobbs,Stephen Kingsmore,Shareef Nahas,Matija Snuderl,John Crawford,Robert J Wechsler-Reya,Tom Belle Davidson,Jennifer Cotter,George Michaiel,Gudrun Fleischhack,Stefan Mundlos,Anthony Schmitt,Hannah Carter,Kulandaimanuvel Antony Michealraj,Sachin A Kumar,Michael D Taylor,Jeremy Rich,Frank Buchholz,Jill P Mesirov,Stefan M Pfister,Ferhat Ay,Jesse R Dixon,Marcel Kool,Lukas Chavez

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation

Tacedinaline (CI-994) 是一种 I 类 HDAC 抑制剂,可靶向 MYC 驱动的髓母细胞瘤的内在肿瘤生长和软脑膜播散,同时使其易受抗 CD47 诱导的巨噬细胞吞噬作用的影响,该作用通过 NF-kB-TGM2 驱动的肿瘤炎症实现

Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Nan Qin, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Allison Cole, Joselyn Cruz-Cruz, Claus M Graef, Matthias Wölfl, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf K

Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions

伴有 ATRX 变异、激酶融合和间变性特征的胶质神经元肿瘤 (GTAKA):一种具有复发性 NTRK 基因融合的分子上不同的脑肿瘤类型

Henri Bogumil, Martin Sill, Daniel Schrimpf, Britta Ismer, Christina Blume, Ramin Rahmanzade, Felix Hinz, Asan Cherkezov, Rouzbeh Banan, Dennis Friedel, David E Reuss, Florian Selt, Jonas Ecker, Till Milde, Kristian W Pajtler, Jens Schittenhelm, Jürgen Hench, Stephan Frank, Henning B Boldt, Bjarne W

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow

使用 SV40 大 T 生成患者来源的儿童毛细胞星形细胞瘤体外模型:建模工作流程评估

Florian Selt, Ahmed El Damaty, Martin U Schuhmann, Romain Sigaud, Jonas Ecker, Philipp Sievers, Daniela Kocher, Christel Herold-Mende, Ina Oehme, Andreas von Deimling, Stefan M Pfister, Felix Sahm, David T W Jones, Olaf Witt, Till Milde

Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

类 HDAC 抑制可降低 MYC 扩增的髓母细胞瘤细胞的 DNA 损伤修复能力

Johanna Vollmer #, Jonas Ecker #, Thomas Hielscher, Gintvile Valinciute, Johannes Ridinger, Nora Jamaladdin, Heike Peterziel, Cornelis M van Tilburg, Ina Oehme, Olaf Witt, Till Milde

Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma

结合 APR-246 与 HDAC 抑制剂:神经母细胞瘤的新型靶向治疗选择

Michael Müller, Lisa Rösch, Sara Najafi, Charlotte Gatzweiler, Johannes Ridinger, Xenia F Gerloff, David T W Jones, Jochen Baßler, Sina Kreth, Sabine Stainczyk, Karen Frese, Benjamin Meder, Frank Westermann, Till Milde, Heike Peterziel, Olaf Witt, Ina Oehme

Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

脑脊液渗透和恩曲替尼联合治疗播散性 ROS1/NTRK 融合阳性儿童高级别胶质瘤

Lisa Mayr, Armin S Guntner, Sibylle Madlener, Maria T Schmook, Andreas Peyrl, Amedeo A Azizi, Karin Dieckmann, Dominik Reisinger, Natalia M Stepien, Kathrin Schramm, Anna Laemmerer, David T W Jones, Jonas Ecker, Felix Sahm, Till Milde, Kristian W Pajtler, Mirjam Blattner-Johnson, Miroslav Strbac, Ch

Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts

在斑马鱼神经母细胞瘤异种移植中对 HDAC 抑制剂治疗的快速体内验证

Jagoda K Wrobel, Sara Najafi, Simay Ayhan, Charlotte Gatzweiler, Damir Krunic, Johannes Ridinger, Till Milde, Frank Westermann, Heike Peterziel, Benjamin Meder, Martin Distel, Olaf Witt, Ina Oehme