日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

天然产物介导的反应劫持机制证实了疟原虫天冬氨酰tRNA合成酶作为抗疟药物靶点的有效性

Ketprasit, Nutpakal; Tai, Chia-Wei; Sharma, Vivek Kumar; Manickam, Yogavel; Khandokar, Yogesh; Ye, Xi; Dogovski, Con; Hilko, David H; Morton, Craig J; Braun, Anne-Sophie C; Leeming, Michael G; Siddharam, Bagale; Shami, Gerald J; Pradeepkumar, Pushpangadan Indira; Panjikar, Santosh; Poulsen, Sally-Ann; Griffin, Michael D W; Sharma, Amit; Tilley, Leann; Xie, Stanley C

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

设计对恶性疟原虫具有体内口服疗效且对人蛋白酶体具有选择性的蛋白酶体抑制剂

Xie, Stanley C; Metcalfe, Riley D; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J; Cohen, Lawrence H; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E; Barry, Daniel C; Liu, Boyin; Gillett, David L; Crespo-Fernandez, Benigno F; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C; Guido, Rafael V C; Baum, Jake; Hanson, Kirsten K; Winzeler, Elizabeth A; Gamo, Francisco-Javier; Fidock, David A; Baud, Delphine; Parker, Michael W; Brand, Stephen; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

基因减毒血期疟疾疫苗的安全性、感染性和免疫原性

Webster, Rebecca; Sekuloski, Silvana; Odedra, Anand; Woolley, Stephen; Jennings, Helen; Amante, Fiona; Trenholme, Katharine R; Healer, Julie; Cowman, Alan F; Eriksson, Emily M; Sathe, Priyanka; Penington, Jocelyn; Blanch, Adam J; Dixon, Matthew W A; Tilley, Leann; Duffy, Michael F; Craig, Alister; Storm, Janet; Chan, Jo-Anne; Evans, Krystal; Papenfuss, Anthony T; Schofield, Louis; Griffin, Paul; Barber, Bridget E; Andrew, Dean; Boyle, Michelle J; de Labastida Rivera, Fabian; Engwerda, Christian; McCarthy, James S

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

旋钮蛋白KAHRP组装成环状结构,该结构是毒力复合体组装的基础。

Looker, Oliver; Blanch, Adam J; Liu, Boyin; Nunez-Iglesias, Juan; McMillan, Paul J; Tilley, Leann; Dixon, Matthew W A

Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects

对感染诺氏疟原虫的红细胞进行多模态分析发现,其存在较大的内陷、宿主细胞肿胀和流变学缺陷。

Liu, Boyin; Blanch, Adam J; Namvar, Arman; Carmo, Olivia; Tiash, Snigdha; Andrew, Dean; Hanssen, Eric; Rajagopal, Vijay; Dixon, Matthew W A; Tilley, Leann

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity

寄生虫介导的合成臭氧化物抗疟药降解影响其体外抗疟活性。

Giannangelo, Carlo; Stingelin, Lukas; Yang, Tuo; Tilley, Leann; Charman, Susan A; Creek, Darren J

Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

疟原虫穿孔素样蛋白 4 在卵动子中肠通过过程中起着至关重要的作用

Deligianni Elena, Silmon de Monerri Natalie C, McMillan Paul J, Bertuccini Lucia, Superti Fabiana, Manola Maria, Spanos Lefteris, Louis Christos, Blackman Michael J, Tilley Leann, Siden-Kiamos Inga