日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

CDKL5 缺乏症大鼠模型中海马 LTP 增强,但 NMDA 受体和 AMPA 受体功能正常

Laura Simões de Oliveira, Heather E O'Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C Davenport, Paul Baxter, Susana R Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K Osterweil, Giles E Hardingham, Michael A Cousin, Sumantra Chattarji, Sam A Booker, Tim A Benke, David J A

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

发现并表征丝氨酸-苏氨酸激酶细胞周期蛋白依赖性激酶样 5 (CDKL5) 的特定抑制剂,证明其在海马 CA1 生理学中发挥作用

Anna Castano #, Margaux Silvestre #, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Lang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navlot S Pabla, Alex N Bullock, Tim A Benke, Sila K Ultani

Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons

Grin2a 的缺失导致海马小清蛋白中间神经元的电生理成熟暂时延迟

Chad R Camp, Anna Vlachos, Chiara Klöckner, Ilona Krey, Tue G Banke, Nima Shariatzadeh, Sarah M Ruggiero, Peter Galer, Kristen L Park, Adam Caccavano, Sarah Kimmel, Xiaoqing Yuan, Hongjie Yuan, Ingo Helbig, Tim A Benke, Johannes R Lemke, Kenneth A Pelkey, Chris J McBain, Stephen F Traynelis

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure

在一次海人参酸诱发的早期癫痫发作后的急性期,长期增强作用增强,AMPA 受体脱敏作用降低

Heather O'Leary, Paul B Bernard, Anna M Castano, Tim A Benke

Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures

FMRP 的磷酸化和 FMRP 复合物的改变是成年大鼠早期癫痫发作引发的 mLTD 增强的原因

Paul B Bernard, Anna M Castano, Heather O'Leary, Kameron Simpson, Michael D Browning, Tim A Benke