日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

快速诱导多能干细胞包涵体病模型揭示了α-突触核蛋白包涵体的形成、后果和分子亚型

Isabel Lam ,Alain Ndayisaba ,Amanda J Lewis ,YuHong Fu ,Giselle T Sagredo ,Anastasia Kuzkina ,Ludovica Zaccagnini ,Meral Celikag ,Jackson Sandoe ,Ricardo L Sanz ,Aazam Vahdatshoar ,Timothy D Martin ,Nader Morshed ,Toru Ichihashi ,Arati Tripathi ,Nagendran Ramalingam ,Charlotte Oettgen-Suazo ,Theresa Bartels ,Manel Boussouf ,Max Schäbinger ,Erinc Hallacli ,Xin Jiang ,Amrita Verma ,Challana Tea ,Zichen Wang ,Hiroyuki Hakozaki ,Xiao Yu ,Kelly Hyles ,Chansaem Park ,Xinyuan Wang ,Thorold W Theunissen ,Haoyi Wang ,Rudolf Jaenisch ,Susan Lindquist ,Beth Stevens ,Nadia Stefanova ,Gregor Wenning ,Wilma D J van de Berg ,Kelvin C Luk ,Rosario Sanchez-Pernaute ,Juan Carlos Gómez-Esteban ,Daniel Felsky ,Yasujiro Kiyota ,Nidhi Sahni ,S Stephen Yi ,Chee Yeun Chung ,Henning Stahlberg ,Isidro Ferrer ,Johannes Schöneberg ,Stephen J Elledge ,Ulf Dettmer ,Glenda M Halliday ,Tim Bartels ,Vikram Khurana

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

MerTK是人类小胶质细胞摄取α-突触核蛋白原纤维的介质

Marie-France Dorion ,Moein Yaqubi ,Konstantin Senkevich ,Nicholas W Kieran ,Adam MacDonald ,Carol X Q Chen ,Wen Luo ,Amber Wallis ,Irina Shlaifer ,Jeffery A Hall ,Roy W R Dudley ,Ian A Glass ,Edward A Fon ,Tim Bartels ,Jack P Antel ,Ziv Gan-Or ,Thomas M Durcan ,Luke M Healy

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

基因表达网络中罕见风险变异负担增加导致散发性帕金森病

Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dett

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

动态生理性 α-突触核蛋白 S129 磷酸化由神经元活动驱动

Nagendran Ramalingam, Shan-Xue Jin #, Tim E Moors #, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V Mosharov, Weish

GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro

GM1 寡糖体外对抗 α-突触核蛋白聚集和毒性的功效

Maria Fazzari, Erika Di Biase, Ludovica Zaccagnini, Alexandre Henriques, Noëlle Callizot, Maria Grazia Ciampa, Laura Mauri, Emma Veronica Carsana, Nicoletta Loberto, Massimo Aureli, Luigi Mari, Monica Civera, Francesca Vasile, Sandro Sonnino, Tim Bartels, Elena Chiricozzi, Giulia Lunghi

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

突触核蛋白病中路易体病理的大脑区域特异性易感性受 α-突触核蛋白构象控制

Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

过量脑源性人类 α-突触核蛋白对突触囊泡运输的影响

Cristina Román-Vendrell, Audrey T Medeiros, John B Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R Morgan

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

对散发性路易体痴呆患者大脑皮层中富含的 α-突触核蛋白种类进行分析

John B Sanderson, Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini, Aurelia Hays Watson, Laura De Boni, Valentina N Lagomarsino, Tracy L Young-Pearse, Xinyue Liu, Thomas C Pochapsky, Bradley T Hyman, Dennis W Dickson, David Klenerman, Dennis J Selkoe, Tim Bartels

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

LRRK2 的家族性敲入突变导致溶酶体功能障碍和内源性不溶性 α-突触核蛋白在神经元中积累

Jason Schapansky, Saurabh Khasnavis, Mark P DeAndrade, Jonathan D Nardozzi, Samuel R Falkson, Justin D Boyd, John B Sanderson, Tim Bartels, Heather L Melrose, Matthew J LaVoie

Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces

通过与脂质界面的瞬时相互作用重新折叠螺旋状可溶性 α-突触核蛋白

Matteo Rovere, John B Sanderson, Luis Fonseca-Ornelas, Dushyant S Patel, Tim Bartels