日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

CTP 合成酶 CTPS1 和 CTPS2 在细胞增殖中的不同作用

Norbert Minet, Anne-Claire Boschat, Rebecca Lane, David Laughton, Philip Beer, Hélène Asnagli, Claire Soudais, Tim Bourne, Alain Fischer, Emmanuel Martin, Sylvain Latour

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

MTHFD2 是一个代谢检查点,控制效应 T 细胞和调节性 T 细胞的命运和功能。

Ayaka Sugiura,Gabriela Andrejeva,Kelsey Voss,Darren R Heintzman,Xincheng Xu,Matthew Z Madden,Xiang Ye,Katherine L Beier,Nowrin U Chowdhury,Melissa M Wolf,Arissa C Young,Dalton L Greenwood,Allison E Sewell,Shailesh K Shahi,Samantha N Freedman,Alanna M Cameron,Patrik Foerch,Tim Bourne,Juan C Garcia-Canaveras,John Karijolich,Dawn C Newcomb,Ashutosh K Mangalam,Joshua D Rabinowitz,Jeffrey C Rathmell

An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

一种口服小分子,靶向可溶性 TNF,在类风湿关节炎中发挥抗 TNF 生物类似药功效

Alexander Vugler, James O'Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Hors

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

针对小分子稳定信号缺陷型 TNF 的构象选择性单克隆抗体

Daniel J Lightwood, Rebecca J Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S Hickford, Antje Schmidt, David Fox 3rd, Alison Maloney, Tom Ceska, Tim Bourne, James O'Connell, Alastair D G Lawson

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

通过稳定扭曲的 TNF 的小分子破坏 TNF-TNFR1 信号传导的结构洞察

David McMillan, Carlos Martinez-Fleites, John Porter, David Fox 3rd, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O'Connell

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

通过稳定三聚体的不对称形式来抑制 TNF 信号传导的小分子

James O'Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox Iii, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling

olokizumab 的发现和特性:一种靶向白细胞介素 6 并中和 gp130 信号的人源化抗体

Stevan Shaw, Tim Bourne, Chris Meier, Bruce Carrington, Rich Gelinas, Alistair Henry, Andrew Popplewell, Ralph Adams, Terry Baker, Steve Rapecki, Diane Marshall, Adrian Moore, Helen Neale, Alastair Lawson

Essential role for CD103 in the T cell-mediated regulation of experimental colitis

CD103 在 T 细胞介导的实验性结肠炎调节中的重要作用

Oliver Annacker, Janine L Coombes, Vivianne Malmstrom, Holm H Uhlig, Tim Bourne, Bengt Johansson-Lindbom, William W Agace, Christina M Parker, Fiona Powrie