Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways
通过联合靶向 MAPK 和 PI3K/mTOR 信号通路克服致癌 BRAF 基因融合单药治疗的耐药性
期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.20949
Payal Jain, Amanda Silva, Harry J Han, Shih-Shan Lang, Yuankun Zhu, Katie Boucher, Tiffany E Smith, Aesha Vakil, Patrick Diviney, Namrata Choudhari, Pichai Raman, Christine M Busch, Tim Delaney, Xiaodong Yang, Aleksandra K Olow, Sabine Mueller, Daphne Haas-Kogan, Elizabeth Fox, Phillip B Storm, Adam
信号转导
肿瘤
WB
MAPK/ERK
PI3K/Akt
mTOR
