Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression
剖析 FMDV Lpro 的不同蛋白水解活性表明，在 I 型干扰素抑制中，RLR 信号蛋白的裂解和降解，而不是其脱ISGylase/DUB 活性
期刊:PLoS Pathogens
影响因子:5.5
doi:10.1371/journal.ppat.1008702
Linda J Visser, Chiara Aloise, Kirby N Swatek, Gisselle N Medina, Karin M Olek, Huib H Rabouw, Raoul J de Groot, Martijn A Langereis, Teresa de Los Santos, David Komander, Tim Skern, Frank J M van Kuppeveld
