日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription

CDK7 的选择性抑制揭示了 TFIIH 在转录中发挥作用的高可信度靶点和新模型

Jenna K Rimel #, Zachary C Poss #, Benjamin Erickson, Zachary L Maas, Christopher C Ebmeier, Jared L Johnson, Tim-Michael Decker, Tomer M Yaron, Michael J Bradley, Kristin B Hamman, Shanhu Hu, Goran Malojcic, Jason J Marineau, Peter W White, Martine Brault, Limei Tao, Patrick DeRoy, Christian Clavet

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

RNA聚合酶II磷酸化调节转录凝聚体和剪接凝聚体之间的转换

Yang Eric Guo # ,John C Manteiga # ,Jonathan E Henninger ,Benjamin R Sabari ,Alessandra Dall'Agnese ,Nancy M Hannett ,Jan-Hendrik Spille ,Lena K Afeyan ,Alicia V Zamudio ,Krishna Shrinivas ,Brian J Abraham ,Ann Boija ,Tim-Michael Decker ,Jenna K Rimel ,Charli B Fant ,Tong Ihn Lee ,Ibrahim I Cisse ,Phillip A Sharp ,Dylan J Taatjes ,Richard A Young

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

介导凝聚体将信号因子定位到关键细胞身份基因

Alicia V Zamudio ,Alessandra Dall'Agnese ,Jonathan E Henninger ,John C Manteiga ,Lena K Afeyan ,Nancy M Hannett ,Eliot L Coffey ,Charles H Li ,Ozgur Oksuz ,Benjamin R Sabari ,Ann Boija ,Isaac A Klein ,Susana W Hawken ,Jan-Hendrik Spille ,Tim-Michael Decker ,Ibrahim I Cisse ,Brian J Abraham ,Tong I Lee ,Dylan J Taatjes ,Jurian Schuijers ,Richard A Young

Analog-sensitive cell line identifies cellular substrates of CDK9

模拟敏感细胞系识别 CDK9 的细胞底物

Tim-Michael Decker, Ignasi Forné, Tobias Straub, Hesham Elsaman, Guoli Ma, Nilay Shah, Axel Imhof, Dirk Eick

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals

RNA 聚合酶 II CTD 的酪氨酸-1 控制哺乳动物基因转录的全局终止

Nilay Shah, Muhammad Ahmad Maqbool, Yousra Yahia, Amal Zine El Aabidine, Cyril Esnault, Ignasi Forné, Tim-Michael Decker, David Martin, Roland Schüller, Stefan Krebs, Helmut Blum, Axel Imhof, Dirk Eick, Jean-Christophe Andrau

CDK9-dependent RNA polymerase II pausing controls transcription initiation

CDK9依赖性RNA聚合酶II暂停控制转录起始

Saskia Gressel #, Björn Schwalb #, Tim Michael Decker, Weihua Qin, Heinrich Leonhardt, Dirk Eick, Patrick Cramer

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1

显性负 Brd4 突变体的转录组分析确定了小分子抑制剂 JQ1 的 Brd4 特异性靶基因

Tim-Michael Decker, Michael Kluge, Stefan Krebs, Nilay Shah, Helmut Blum, Caroline C Friedel, Dirk Eick