Genetic depletion of early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to M1 inflammatory mode, and compromises myelin integrity in skeletal muscle.
早期自噬蛋白 ATG13 的基因缺失会损害线粒体能量代谢，增强氧化应激，诱导巨噬细胞极化为 M1 炎症模式，并损害骨骼肌中的髓鞘完整性
期刊:
影响因子:
doi:10.21203/rs.3.rs-7189456/v1
Toriola Mubaraq A, Timlin Emma, Bulbule Sarojini, Reyes Amy, Adedeji Omolola Mary, Gottschalk C Gunnar, Barua Animesh, Arnold Leggy A, Roy Avik
代谢
细胞生物学
Autophagy
巨噬细胞
氧化应激
炎症
线粒体
自噬
