日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy

利用易发生抗体依赖性细胞毒性（ADCC）的纳米抗体构建体清除肿瘤浸润的IL1R2+调节性T细胞，可提高抗PD-1免疫疗法的疗效。

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-24-3095
Sana M Arnouk ，Daliya Kancheva ，Helena Van Damme ，Guillaume E Courtoy ，Romina Mora Barthelmess ，Jolien Van Craenenbroeck ，Els Lebegge ，Yvon Elkrim ，Naela Assaf ，Yves Heremans ，Aleksandar Murgaski ，Timo W M De Groof ，Emile Clappaert ，Ayla Debraekeleer ，Jan Brughmans ，Gillian Blancke ，Máté Kiss ，Ramses Forsyth ，Wim Waelput ，Louis Boon ，Nick Devoogdt ，Catelijne Stortelers ，Nadja van Boxel ，Bruno Dombrecht ，Lars Vereecke ，Cécile Vincke ，Geert Raes ，Damya Laoui ，Jo A Van Ginderachter
免疫/内分泌
肿瘤
IL1R2
PD-1
T细胞
发表日期：2025
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Optimizing antibody PET imaging: a comparative preclinical analysis of nanobody and minibody-like PET tracers

优化抗体PET成像：纳米抗体和迷你抗体样PET示踪剂的临床前比较分析

期刊:European Journal of Nuclear Medicine and Molecular Imaging
影响因子:8.6
doi:10.1007/s00259-025-07205-2.
Katty Zeven ,Herlinde Dierick ,Matthijs Sevenois ,Henri Baudhuin ,Laurent Navarro ,Sonja Van den Block ,Jelena Saliën ,Karine Breckpot ,Jessica Bridoux ,Timo W M De Groof # ,Nick Devoogdt #
发表日期：2025
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Preclinical development and selection of nanobody-based CAR-T cells targeting HER2-positive solid tumors

针对HER2阳性实体瘤的纳米抗体CAR-T细胞的临床前开发和筛选

期刊:Molecular Therapy Oncology
影响因子:5.3
doi:10.1016/j.omton.2025.201088
Meeus, Fien; Van der Vreken, Arne; Autaers, Dorien; De Groof, Timo W M; Esprit, Arthur; Franceschini, Lorenzo; Parone, Philippe; Goyvaerts, Cleo; De Vlaeminck, Yannick; Devoogdt, Nick; Breckpot, Karine
T细胞
HER2
T细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Design and Preclinical Validation of an Anti-B7-H3-Specific Radiotracer: A Non-Invasive Imaging Tool to Guide B7-H3-Targeted Therapies

抗B7-H3特异性放射性示踪剂的设计与临床前验证：一种指导B7-H3靶向治疗的非侵入性成像工具

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph18101477
Funeh, Cyprine Neba; Meeus, Fien; Van Winnendael, Niels; De Groof, Timo W M; D'Huyvetter, Matthias; Devoogdt, Nick
发表日期：2025
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Nanobody-based Pannexin1 channel inhibitors increase survival after cardiac ischemia/reperfusion

基于纳米抗体的Pannexin1通道抑制剂可提高心肌缺血/再灌注后的存活率。

期刊:Cell and Tissue Research
影响因子:2.9
doi:10.1007/s00441-025-03994-y
Rusiecka, Olga M; Molica, Filippo; Clochard, Linda; Van Campenhout, Raf; De Groof, Timo W M; Bes, Viviane; Devoogdt, Nick; Muyldermans, Serge; Vinken, Mathieu; Kwak, Brenda R
心血管
发表日期：2025
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery

新型泛癌抗uPAR荧光纳米抗体的制备与表征及其在图像引导手术中的应用

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202400700
Mateusiak, Łukasz; Floru, Sam; De Groof, Timo W M; Wouters, Janne; Declerck, Noemi B; Debie, Pieterjan; Janssen, Simone; Zeven, Katty; Puttemans, Janik; Vincke, Cécile; Breckpot, Karine; Devoogdt, Nick; Hernot, Sophie
肿瘤
IF
肿瘤免疫
uPA
uPAR
发表日期：2024
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AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia

AXL 特异性单域抗体在急性髓系白血病中表现出诊断潜力和抗肿瘤活性

期刊:Theranostics
影响因子:12.4
doi:10.7150/thno.91456
Niels Vandewalle, Hatice Satilmis, Emma Verheye, Rong Fan, Yanmeng Wang, Timo W M De Groof, Jessica Bridoux, Tessa Kerre, Nathan De Beule, Ann De Becker, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Karine Breckpot, Nick Devoogdt, Kim De Veirman
肿瘤
白血病
发表日期：2024
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Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer

利用基于 CD163 特异性纳米抗体的免疫示踪剂对免疫治疗期间肿瘤相关巨噬细胞的动态变化进行成像

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2409668121
Lauwers, Yoline; De Groof, Timo W M; Vincke, Cécile; Van Craenenbroeck, Jolien; Jumapili, Neema Ahishakiye; Barthelmess, Romina Mora; Courtoy, Guillaume; Waelput, Wim; De Pauw, Tessa; Raes, Geert; Devoogdt, Nick; Van Ginderachter, Jo A
巨噬细胞
肿瘤
肿瘤免疫
细胞生物学
巨噬细胞
CD163
CD16
免疫/内分泌
发表日期：2024
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Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β

利用针对人CD8β的纳米抗体放射性示踪剂对CD8+T细胞动态进行特异性成像

期刊:European Journal of Nuclear Medicine and Molecular Imaging
影响因子:7.6
doi:10.1007/s00259-024-06896-3
De Groof, Timo W M; Lauwers, Yoline; De Pauw, Tessa; Saxena, Mohit; Vincke, Cécile; Van Craenenbroeck, Jolien; Chapon, Catherine; Le Grand, Roger; Raes, Geert; Naninck, Thibaut; Van Ginderachter, Jo A; Devoogdt, Nick
T细胞
CD8
T细胞
细胞生物学
免疫/内分泌
发表日期：2024
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Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization

仔细检查胞外域对嵌合抗原受体的激活：针对多发性骨髓瘤细胞的单域抗体的经验凸显了逐案优化的必要性

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2024.1389018
Heleen Hanssens, Fien Meeus, Yannick De Vlaeminck, Quentin Lecocq, Janik Puttemans, Pieterjan Debie, Timo W M De Groof, Cleo Goyvaerts, Kim De Veirman #, Karine Breckpot #, Nick Devoogdt #
免疫
细胞生物学
骨髓瘤
其它细胞
发表日期：2024
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