日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer

序贯 ALK 抑制剂可在 ALK 阳性肺癌中筛选出对劳拉替尼具有耐药性的化合物 ALK 突变

Satoshi Yoda, Jessica J Lin, Michael S Lawrence, Benjamin J Burke, Luc Friboulet, Adam Langenbucher, Leila Dardaei, Kylie Prutisto-Chang, Ibiayi Dagogo-Jack, Sergei Timofeevski, Harper Hubbeling, Justin F Gainor, Lorin A Ferris, Amanda K Riley, Krystina E Kattermann, Daria Timonina, Rebecca S Heist,

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

激活B因子:激活ALK突变可增加未磷酸化激酶的蛋白质动力学

Johnson, Ted W; Bolanos, Ben; Brooun, Alexei; Gallego, Rebecca A; Gehlhaar, Dan; Jalaie, Mehran; McTigue, Michele; Timofeevski, Sergei

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

有丝分裂检查点激酶 Mps1 在正常生理学中发挥作用,影响临床效用

Ricardo Martinez, Alessandra Blasina, Jill F Hallin, Wenyue Hu, Isha Rymer, Jeffery Fan, Robert L Hoffman, Sean Murphy, Matthew Marx, Gina Yanochko, Dusko Trajkovic, Dac Dinh, Sergei Timofeevski, Zhou Zhu, Peiquing Sun, Patrick B Lappin, Brion W Murray

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

对 PI3Kα 的分离 p110α 亚基进行工程改造,使其能够结晶,并为基于结构的药物设计提供平台

Ping Chen, Ya-Li Deng, Simon Bergqvist, Matthew D Falk, Wei Liu, Sergei Timofeevski, Alexei Brooun

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

脂质激活剂和小分子抑制剂对蛋白激酶 N 家族激酶的酶动力学和不同调节

Matthew D Falk, Wei Liu, Ben Bolaños, Keziban Unsal-Kacmaz, Anke Klippel, Stephan Grant, Alexei Brooun, Sergei Timofeevski

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase

c-Jun 激酶小分子抑制剂的药理学表征

Helen Cho, Shawn C Black, David Looper, Manli Shi, Dawn Kelly-Sullivan, Sergei Timofeevski, Karen Siegel, Xiao-Hong Yu, Scott R McDonnell, Ping Chen, Junming Yie, Kathleen M Ogilvie, James Fraser, Celia P Briscoe