日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions

通过 PS-ASO-蛋白-TLR9 相互作用洞察先天免疫激活

Adam J Pollak, Luyi Zhao, Timothy A Vickers, Ian J Huggins, Xue-Hai Liang, Stanley T Crooke

NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides

NAT10 和 DDX21 蛋白与 RNase H1 相互作用并影响硫代磷酸酯寡核苷酸的性能

Lingdi Zhang, Karla D Bernardo, Timothy A Vickers, Jun Tian, Xue-Hai Liang, Stanley T Crooke

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

迈向下一代反义寡核苷酸:甲磺酰基磷酰胺修饰可改善间隙体反义寡核苷酸的治疗指数和作用持续时间

Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Michael E Østergaard, Michael T Migawa, Michael Fazio, W Brad Wan, Andres Berdeja, Eli Scandalis, Sebastien A Burel, Timothy A Vickers, Stanley T Crooke, Eric E Swayze, Xuehai Liang, Punit P Seth

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

硫代磷酸酯寡核苷酸与 RNase H1 的结合可引起蛋白质构象变化,并改变 RNase H1 与其他蛋白质的相互作用

Lingdi Zhang, Timothy A Vickers, Hong Sun, Xue-Hai Liang, Stanley T Crooke

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1

PS-ASO/蛋白质与 P54nrb 和 RNase H1 相互作用的动力学和亚细胞分析

Timothy A Vickers, Meghdad Rahdar, Thazha P Prakash, Stanley T Crooke

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

表皮生长因子受体介导的细胞摄取促进硫代磷酸酯修饰的反义寡核苷酸的细胞内活性

Shiyu Wang, Nickolas Allen, Timothy A Vickers, Alexey S Revenko, Hong Sun, Xue-Hai Liang, Stanley T Crooke

Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

2'氟修饰的5-10-5间隙体硫代磷酸酯寡核苷酸在小鼠中的急性肝毒性与细胞内蛋白质结合和DBHS蛋白质的丢失有关

Wen Shen, Cheryl L De Hoyos, Hong Sun, Timothy A Vickers, Xue-Hai Liang, Stanley T Crooke

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

针对上游开放阅读框的反义寡核苷酸可提高 mRNA 的翻译效率

Xue-Hai Liang, Wen Shen, Hong Sun, Michael T Migawa, Timothy A Vickers, Stanley T Crooke

Modulation of LMNA splicing as a strategy to treat prelamin A diseases

调节 LMNA 剪接作为治疗前层蛋白 A 疾病的策略

John M Lee, Chika Nobumori, Yiping Tu, Catherine Choi, Shao H Yang, Hea-Jin Jung, Timothy A Vickers, Frank Rigo, C Frank Bennett, Stephen G Young, Loren G Fong

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

开发用于核酸-蛋白质相互作用的定量 BRET 亲和力测定法

Timothy A Vickers, Stanley T Crooke