日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

重症血友病 A 犬 AAV 基因治疗后多中心淋巴瘤载体基因组整合分析

Lucas Van Gorder, Bhavya S Doshi, Elinor Willis, Timothy C Nichols, Emma Cook, John K Everett, Elizabeth P Merricks, Valder R Arruda, Frederic D Bushman, Mary Beth Callan, Benjamin J Samelson-Jones

Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4-driven transcriptional state

小细胞肺癌中对LSD1抑制剂的固有耐药性和获得性耐药性是通过TEAD4驱动的转录状态发生的。

Wen Yan ,Chi-Yeh Chung ,Tao Xie ,Mark Ozeck ,Timothy C Nichols ,Jessica Frey ,Akshata R Udyavar ,Shikhar Sharma ,Thomas A Paul

Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog

植入犬肝细胞的嵌合小鼠表现出与血友病 B 犬相似的 AAV 转导效率

Wenwei Shao, Junjiang Sun, Xiaojing Chen, Amanda Dobbins, Elizabeth P Merricks, R Jude Samulski, Timothy C Nichols, Chengwen Li

Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction

腺相关病毒长期转导后后期给予地塞米松可暂时增强肝脏中的转基因表达

Zheng Chai, Xintao Zhang, Amanda Lee Dobbins, Richard Jude Samulski, Elizabeth P Merricks, Timothy C Nichols, Chengwen Li

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

对患有血友病 A 的狗进行 AAV 基因治疗的长期研究发现,转导肝细胞出现克隆扩增

Giang N Nguyen #, John K Everett #, Samita Kafle, Aoife M Roche, Hayley E Raymond, Jacob Leiby, Christian Wood, Charles-Antoine Assenmacher, Elizabeth P Merricks, C Tyler Long, Haig H Kazazian, Timothy C Nichols, Frederic D Bushman, Denise E Sabatino

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

具有人类肝细胞趋向性和中和抗体逃逸能力的 AAV 变体的开发

Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Caibin Cui, Yasmina L Abajas, David A Gerber, Elizabeth P Merricks, Timothy C Nichols, Wuping Li, R Jude Samulski, Chengwen Li

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

冠状动脉疾病风险相关基因Plpp3及其产物脂质磷酸酯酶3调控实验性动脉粥样硬化

Paul A Mueller, Liping Yang, Margo Ubele, Guogen Mao, Jason Brandon, Julia Vandra, Timothy C Nichols, Diana Escalante-Alcalde, Andrew J Morris, Susan S Smyth

Superior human hepatocyte transduction with adeno-associated virus vector serotype 7

腺相关病毒载体血清型7对人类肝细胞的卓越转导

Wenwei Shao, Xiaolei Pei, Caibin Cui, Charles Askew, Amanda Dobbins, Xiaojing Chen, Yasmina L Abajas, David A Gerber, R Jude Samulski, Timothy C Nichols, Chengwen Li

Influence of diabetes on the foreign body response to nitric oxide-releasing implants

糖尿病对异物对释放一氧化氮的植入物反应的影响

Robert J Soto, Elizabeth P Merricks, Dwight A Bellinger, Timothy C Nichols, Mark H Schoenfisch

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs

对两只血友病犬进行长期 AAV 重复给药的观察性研究

Junjiang Sun, Wenwei Shao, Xiaojing Chen, Elizabeth P Merricks, Lauren Wimsey, Yasmina L Abajas, Glenn P Niemeyer, Clinton D Lothrop, Paul E Monahan, R Jude Samulski, Timothy C Nichols, Chengwen Li