日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms

MLK3 介导 PKG1α 对心脏功能的影响并通过不同的机制控制血压

Timothy D Calamaras, Suchita Pande, Robert Au Baumgartner, Seung Kyum Kim, Joseph C McCarthy, Gregory L Martin, Kelly Tam, Angela L McLaughlin, Guang-Rong Wang, Mark J Aronovitz, Weiyu Lin, Jonathan I Aguirre, Paulina Baca, Peiwen Liu, Daniel A Richards, Roger J Davis, Richard H Karas, Iris Z Jaffe,

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload

混合谱系激酶-3 可预防压力超负荷导致的心脏功能障碍和结构重塑

Timothy D Calamaras, Robert A Baumgartner, Mark J Aronovitz, Angela L McLaughlin, Kelly Tam, Daniel A Richards, Craig W Cooper, Nathan Li, Wendy E Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J Davis, Navin K Kapur, Richard H Karas, Robert M Blanton

Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice

小鼠横主动脉缩窄三种程度引起的不同表型

Daniel A Richards, Mark J Aronovitz, Timothy D Calamaras, Kelly Tam, Gregory L Martin, Peiwen Liu, Heather K Bowditch, Phyllis Zhang, Gordon S Huggins, Robert M Blanton

Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease

线粒体活性氧介导饮食引起的代谢性心脏病对心脏结构、功能和线粒体的影响

Aaron L Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B Behring, Ivan Luptak, Timothy D Calamaras, Deborah A Siwik, Edward J Miller, Marc Liesa, Orian S Shirihai, David R Pimentel, Richard A Cohen, Markus M Bachschmid, Wilson S Colucci

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling

脂质过氧化产物 4-羟基-反式-2-壬烯醛通过激活 mTORC1-p70S6K-RPS6 信号引起心肌细胞中的蛋白质合成

Timothy D Calamaras, Charlie Lee, Fan Lan, Yasuo Ido, Deborah A Siwik, Wilson S Colucci

Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity

通过在赖氨酸残基 97 处加合活性脂质 4-羟基-反式-2-壬烯醛 (HNE) 对丝氨酸/苏氨酸激酶 LKB1 进行翻译后修饰,直接抑制激酶活性

Timothy D Calamaras, Charlie Lee, Fan Lan, Yasuo Ido, Deborah A Siwik, Wilson S Colucci