日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

ZBP1和cGAS协同感知线粒体DNA促进心脏毒性

Yuanjiu Lei,Jordyn J VanPortfliet,Yi-Fan Chen,Joshua D Bryant,Ying Li,Danielle Fails,Sylvia Torres-Odio,Katherine B Ragan,Jingti Deng,Armaan Mohan,Bing Wang,Olivia N Brahms,Shawn D Yates,Michael Spencer,Carl W Tong,Marcus W Bosenberg,Laura Ciaccia West,Gerald S Shadel,Timothy E Shutt,Jason W Upton,Pingwei Li,A Phillip West

Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3

丁酸盐可减轻粘附性侵袭性大肠杆菌引起的上皮线粒体形态和屏障功能的破坏:游离脂肪酸受体 3 的参与

Samira A Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L Prince, Ian A Lewis, Jane Shearer, Åsa V Keita, Johan D Söderholm, Timothy E Shutt, Derek M McKay

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

在线粒体拓扑异构酶 TOP1MT 缺陷的细胞中激活 cGAS-STING 先天免疫反应

Iman Al Khatib, Jingti Deng, Yuanjiu Lei, Sylvia Torres-Odio, Gladys R Rojas, Laura E Newman, Brian K Chung, Andrew Symes, Hongliang Zhang, Shar-Yin N Huang, Yves Pommier, Aneal Khan, Gerald S Shadel, Andrew Phillip West, William T Gibson, Timothy E Shutt

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome

影响线粒体基因组调控的线粒体拓扑异构酶 TOP1MT 的两种变体的功能表征

Iman Al Khatib, Jingti Deng, Andrew Symes, Marina Kerr, Hongliang Zhang, Shar-Yin Naomi Huang, Yves Pommier, Aneal Khan, Timothy E Shutt

Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss

患有共济失调、视神经萎缩和神经性听力损失的患者中 MFN2 的 HR1 结构域中新变体的表征

Govinda Sharma, Mashiat Zaman, Rasha Sabouny, Matthew Joel, Kristina Martens, Davide Martino, A P Jason de Koning, Gerald Pfeffer, Timothy E Shutt

Crohn's Disease Pathobiont Adherent-Invasive E coli Disrupts Epithelial Mitochondrial Networks With Implications for Gut Permeability

克罗恩病致病菌粘附侵袭性大肠杆菌破坏上皮线粒体网络,对肠道通透性产生影响

Nicole L Mancini, Sruthi Rajeev, Timothy S Jayme, Arthur Wang, Åsa V Keita, Matthew L Workentine, Samira Hamed, Johan D Söderholm, Fernando Lopes, Timothy E Shutt, Jane Shearer, Derek M McKay

Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells

泛素羧基末端水解酶 L1 的缺失会损害小鼠精原干细胞的长期分化能力和代谢调节

Whitney F Alpaugh, Anna L Voigt, Rkia Dardari, Lin Su, Iman Al Khatib, Wisoo Shin, Taylor M Goldsmith, Krysta M Coyle, Lin A Tang, Timothy E Shutt, Claudia Klein, Jeff Biernaskie, Ina Dobrinski

A new automated tool to quantify nucleoid distribution within mitochondrial networks

一种量化线粒体网络内核苷分布的新型自动化工具

Hema Saranya Ilamathi #, Mathieu Ouellet #, Rasha Sabouny, Justine Desrochers-Goyette, Matthew A Lines, Gerald Pfeffer, Timothy E Shutt, Marc Germain

Aberrant Mitochondrial Morphology and Function in the BTBR Mouse Model of Autism Is Improved by Two Weeks of Ketogenic Diet

两周生酮饮食可改善自闭症 BTBR 小鼠模型中异常的线粒体形态和功能

Younghee Ahn, Rasha Sabouny, Bianca R Villa, Nellie C Yee, Richelle Mychasiuk, Golam M Uddin, Jong M Rho, Timothy E Shutt

PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes

PISD 是一种线粒体疾病基因,可导致骨骼发育不良、白内障和白质变化

Tian Zhao, Caitlin M Goedhart, Pingdewinde N Sam, Rasha Sabouny, Susanne Lingrell, Adam J Cornish, Ryan E Lamont, Francois P Bernier, David Sinasac, Jillian S Parboosingh; Care4Rare Canada Consortium; Jean E Vance, Steven M Claypool, A Micheil Innes, Timothy E Shutt